气候变化领域集成服务门户(CCPortal): Coccidioidomycosis in Oklahoma: A retrospective case series

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DOI	10.1111/myc.13749
	Coccidioidomycosis in Oklahoma: A retrospective case series
	Scott, Brian; Sassine, Joseph; Gordon, Olivia; Higuita, Nelson Ivan Agudelo
发表日期	2024
ISSN	0933-7407
EISSN	1439-0507
起始页码	67
结束页码	5
卷号	67 期号:5
英文摘要	BackgroundCoccidioidomycosis is a systemic fungal disease endemic to arid regions of the Western Hemisphere. In the south-western US, Coccidioides spp. may account for up to 20%-25% of all cases of community acquired pneumonia. Clinical manifestations vary widely, from asymptomatic infection to life-threatening disease, especially in immunocompromised hosts.ObjectivesThe primary objective of the study was to characterise cases of coccidioidomycosis in an area of the United States not considered traditionally endemic for the disease.MethodsWe performed a single-centre retrospective study of all cases of coccidioidomycosis from 1 January 2000 to 31 December 2020, in the University of Oklahoma Health Sciences Medical Center.ResultsA total of 26 patients were included for analysis. The central nervous system (CNS) and the lungs were the sites most frequently involved. Twenty (77%) had travelled to a coccidioidomycosis endemic region. Most were male (81%) with a median age of 42 years (range: 3-78 years). The majority (46%) were Caucasians, 19% were African American, 19% Hispanic, and 12% Native American. The most common comorbidities were diabetes mellitus and acquired immunodeficiency syndrome, identified in 27% and 23% of patients, respectively. Patients on immunosuppressive therapy accounted for 12% of all cases.ConclusionOur study is one of the largest single-centre case series of coccidioidomycosis from a non-endemic area. Diabetes mellitus was the most frequent comorbidity. Compared to other case series of coccidioidomycosis, our patient population had higher rates of immunosuppression and had both a higher rate of disseminated disease and overall mortality.
英文关键词	climate change; coccidioidomycosis; Oklahoma; Valley fever
语种	英语
WOS研究方向	Dermatology ; Mycology
WOS类目	Dermatology ; Mycology
WOS记录号	WOS:001229766000001
来源期刊	MYCOSES
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/298482
作者单位	University of Oklahoma System; University of Oklahoma Health Sciences Center; University of Oklahoma System; University of Oklahoma Health Sciences Center
推荐引用方式 GB/T 7714	Scott, Brian,Sassine, Joseph,Gordon, Olivia,et al. Coccidioidomycosis in Oklahoma: A retrospective case series[J],2024,67(5).
APA	Scott, Brian,Sassine, Joseph,Gordon, Olivia,&Higuita, Nelson Ivan Agudelo.(2024).Coccidioidomycosis in Oklahoma: A retrospective case series.MYCOSES,67(5).
MLA	Scott, Brian,et al."Coccidioidomycosis in Oklahoma: A retrospective case series".MYCOSES 67.5(2024).