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| DOI | 10.1038/s41598-024-59157-6 |
| Putative climate adaptation in American pikas (Ochotona princeps) is associated with copy number variation across environmental gradients | |
| 发表日期 | 2024 |
| ISSN | 2045-2322 |
| 起始页码 | 14 |
| 结束页码 | 1 |
| 卷号 | 14期号:1 |
| 英文摘要 | Improved understanding of the genetic basis of adaptation to climate change is necessary for maintaining global biodiversity moving forward. Studies to date have largely focused on sequence variation, yet there is growing evidence that suggests that changes in genome structure may be an even more significant source of adaptive potential. The American pika (Ochotona princeps) is an alpine specialist that shows some evidence of adaptation to climate along elevational gradients, but previous work has been limited to single nucleotide polymorphism based analyses within a fraction of the species range. Here, we investigated the role of copy number variation underlying patterns of local adaptation in the American pika using genome-wide data previously collected across the entire species range. We identified 37-193 putative copy number variants (CNVs) associated with environmental variation (temperature, precipitation, solar radiation) within each of the six major American pika lineages, with patterns of divergence largely following elevational and latitudinal gradients. Genes associated (n = 158) with independent annotations across lineages, variables, and/or CNVs had functions related to mitochondrial structure/function, immune response, hypoxia, olfaction, and DNA repair. Some of these genes have been previously linked to putative high elevation and/or climate adaptation in other species, suggesting they may serve as important targets in future studies. |
| 英文关键词 | Copy number variant; Local adaptation; Climate; RADseq; Latitudinal and elevational gradients |
| 语种 | 英语 |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:001201866300006 |
| 来源期刊 | SCIENTIFIC REPORTS
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/297167 |
| 作者单位 | University of British Columbia; Northern Michigan University |
| 推荐引用方式 GB/T 7714 | . Putative climate adaptation in American pikas (Ochotona princeps) is associated with copy number variation across environmental gradients[J],2024,14(1). |
| APA | (2024).Putative climate adaptation in American pikas (Ochotona princeps) is associated with copy number variation across environmental gradients.SCIENTIFIC REPORTS,14(1). |
| MLA | "Putative climate adaptation in American pikas (Ochotona princeps) is associated with copy number variation across environmental gradients".SCIENTIFIC REPORTS 14.1(2024). |
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