气候变化领域集成服务门户(CCPortal): Potential roles of hydroxybenzoate paralytic shellfish toxins in modulating toxin biokinetics in scallops

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DOI	10.1016/j.jhazmat.2024.133896
	Potential roles of hydroxybenzoate paralytic shellfish toxins in modulating toxin biokinetics in scallops
	Lin, Zhuo-Ru; Geng, Hui-Xia; Yu, Ren-Cheng
发表日期	2024
ISSN	0304-3894
EISSN	1873-3336
起始页码	469
卷号	469
英文摘要	Paralytic shellfish toxins (PSTs) produced by some marine dinoflagellates can cause severe human intoxication via vectors like bivalves. Toxic dinoflagellate Gymnodinium catenatum produce a novel group of hydroxybenzoate PSTs named GC toxins, but their biokinetics in bivalves haven't been well examined. In this experiment, we analyzed PSTs in bay scallops Argopecten irradians exposed to G. catenatum (strain MEL11) to determine their accumulation, elimination, anatomical distribution, and biotransformation. To our surprise, up to 30% of the PSTs were accumulated in the adductor muscle of scallops at the end of the experiment, and the toxicity of adductor muscle exceeded the regulatory limit of 800 mu g STXeq/kg in only 6 days. High concentration of toxins in the adductor muscle are likely linked to the rapid transfer of GC toxins from viscera to other tissues. Moreover, most GC toxins in scallops were found rapidly transformed to decarbamoyl toxins through enzyme-mediated hydrolysis, which was further supported by the in vitro incubation experiments. Our study demonstrates that GC toxins actively participate in toxin distribution and transformation in scallops, which may increase the risks of food poisoning associated with the consumption of scallop adductor muscle. Environmental implication: The negative impacts of harmful algal blooms (HABs) have become a global environmental concern under the joint effects of cultural eutrophication and climate change. Our study, targeted on
英文关键词	Gymnodinium catenatum; Argopecten irradians; Paralytic shellfish poisoning; GC toxins
语种	英语
WOS研究方向	Engineering ; Environmental Sciences & Ecology
WOS类目	Engineering, Environmental ; Environmental Sciences
WOS记录号	WOS:001210925400001
来源期刊	JOURNAL OF HAZARDOUS MATERIALS
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/296589
作者单位	Chinese Academy of Sciences; Institute of Oceanology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of Oceanology, CAS
推荐引用方式 GB/T 7714	Lin, Zhuo-Ru,Geng, Hui-Xia,Yu, Ren-Cheng. Potential roles of hydroxybenzoate paralytic shellfish toxins in modulating toxin biokinetics in scallops[J],2024,469.
APA	Lin, Zhuo-Ru,Geng, Hui-Xia,&Yu, Ren-Cheng.(2024).Potential roles of hydroxybenzoate paralytic shellfish toxins in modulating toxin biokinetics in scallops.JOURNAL OF HAZARDOUS MATERIALS,469.
MLA	Lin, Zhuo-Ru,et al."Potential roles of hydroxybenzoate paralytic shellfish toxins in modulating toxin biokinetics in scallops".JOURNAL OF HAZARDOUS MATERIALS 469(2024).