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DOI	10.1016/j.scitotenv.2024.172146
	Temperature-dependent toxicity of fluoxetine alters the thermal plasticity of marine diatoms
	Li, Zhenzhen; Gaitan-Espitia, Juan Diego
发表日期	2024
ISSN	0048-9697
EISSN	1879-1026
起始页码	926
卷号	926
英文摘要	Anthropogenic activities have led to the emergence of pharmaceutical pollution in marine ecosystems, posing a significant threat to biodiversity in conjunction with global climate change. While the ecotoxicity of human drugs on aquatic organisms is increasingly recognized, their interactions with environmental factors, such as temperature, remain understudied. This research investigates the physiological effects of the selective serotonin reuptake inhibitor (SSRI), fluoxetine, on two diatom species, Phaeodactylum tricornutum and Thalassiosira weissflogii. Results demonstrate that fluoxetine significantly reduces growth rate and biomass production, concurrently affecting pigment contents and the thermal performance curve (TPC) of the diatoms. Fluoxetine reduces the synthesis of chlorophyll a (Chl a) and carotenoid (Car), indicating inhibition of photosynthesis and photoprotection. Furthermore, fluoxetine decreases the maximum growth rate (mu max) while increasing the optimum temperature (Topt) in both species, suggesting an altered thermal plasticity. This shift is attributed to the observed decrease in the inhibition rate of fluoxetine with rising temperatures. These findings emphasize the physiological impacts and ecological implications of fluoxetine on phytoplankton and underscore the significance of considering interactions between multiple environmental drivers when accessing the ecotoxicity of potential pollutants. The present study provides insights into crucial considerations for evaluating the impacts of pharmaceutical pollution on marine primary producers.
英文关键词	Pharmaceutical pollution; Fluoxetine; Diatoms; Ecotoxicity; Environmental interactions; Thermal performance curve
语种	英语
WOS研究方向	Environmental Sciences & Ecology
WOS类目	Environmental Sciences
WOS记录号	WOS:001224226600001
来源期刊	SCIENCE OF THE TOTAL ENVIRONMENT
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/296266
作者单位	University of Hong Kong; University of Hong Kong
推荐引用方式 GB/T 7714	Li, Zhenzhen,Gaitan-Espitia, Juan Diego. Temperature-dependent toxicity of fluoxetine alters the thermal plasticity of marine diatoms[J],2024,926.
APA	Li, Zhenzhen,&Gaitan-Espitia, Juan Diego.(2024).Temperature-dependent toxicity of fluoxetine alters the thermal plasticity of marine diatoms.SCIENCE OF THE TOTAL ENVIRONMENT,926.
MLA	Li, Zhenzhen,et al."Temperature-dependent toxicity of fluoxetine alters the thermal plasticity of marine diatoms".SCIENCE OF THE TOTAL ENVIRONMENT 926(2024).