气候变化领域集成服务门户(CCPortal): Determinants of thermal homeostasis in the preimplantation embryo: a role for the embryo's central heating system?

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DOI	10.1007/s10815-024-03130-9
	Determinants of thermal homeostasis in the preimplantation embryo: a role for the embryo's central heating system?
	Leese, Henry J.; Sturmey, Roger G.
发表日期	2024
ISSN	1058-0468
EISSN	1573-7330
英文摘要	A number of factors may impinge on thermal homeostasis in the early embryo. The most obvious is the ambient temperature in which development occurs. Physiologically, the temperature in the lumen of the female tract is typically lower than the core body temperature, yet rises at ovulation in the human, while in an IVF setting, embryos are usually maintained at core body temperature. However, internal cellular developmental processes may modulate thermal control within the embryo itself, especially those occurring in the mitochondria which generate intracellular heat through proton leak and provide the embryo with its own 'central heating system'. Moreover, mitochondrial movements may serve to buffer high local intracellular temperatures. It is also notable that the preimplantation stages of development would generate proportionally little heat within their mitochondria until the blastocyst stage as mitochondrial metabolism is comparatively low during the cleavage stages. Despite these data, the specific notion of thermal control of preimplantation development has received remarkably scant consideration. This opinion paper illustrates the lack of reliable quantitative data on these markers and identifies a major research agenda which needs to be addressed with urgency in view of laboratory conditions in which embryos are maintained as well as climate change-derived heat stress which has a negative effect on numerous clinical markers of early human embryo development.
英文关键词	Thermal regulation; Embryo development; Mitochondrial function
语种	英语
WOS研究方向	Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
WOS类目	Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
WOS记录号	WOS:001218950700001
来源期刊	JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/295335
作者单位	University of Hull; University of York - UK; University of York - UK; University of Hull
推荐引用方式 GB/T 7714	Leese, Henry J.,Sturmey, Roger G.. Determinants of thermal homeostasis in the preimplantation embryo: a role for the embryo's central heating system?[J],2024.
APA	Leese, Henry J.,&Sturmey, Roger G..(2024).Determinants of thermal homeostasis in the preimplantation embryo: a role for the embryo's central heating system?.JOURNAL OF ASSISTED REPRODUCTION AND GENETICS.
MLA	Leese, Henry J.,et al."Determinants of thermal homeostasis in the preimplantation embryo: a role for the embryo's central heating system?".JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2024).