气候变化领域集成服务门户(CCPortal): Malus toringoides (Rehd.) Hughes decoction alleviates isoproterenol-induced cardiac fibrosis by inhibiting cardiomyocyte inflammation and pyroptosis via the HK1/NLRP3 signaling pathway

CCPortal

DOI	10.1093/bbb/zbae055
	Malus toringoides (Rehd.) Hughes decoction alleviates isoproterenol-induced cardiac fibrosis by inhibiting cardiomyocyte inflammation and pyroptosis via the HK1/NLRP3 signaling pathway
	Du, Huiru; Zhang, Yuling; Guo, Haochuan; Cheng, Xizhen; Tian, Haolin; Wang, Yanan; Wang, Hongfang; Song, Yongxing; Duan, Xuhong; Ma, Donglai
发表日期	2024
ISSN	0916-8451
EISSN	1347-6947
英文摘要	Malus toringoides (Rehd.) Hughes, called Eseye (Ese), is a traditional medicinal plant from the Tibet province of China that has proven effective in treating cardiac conditions due to its anti-inflammatory, antioxidative, and antiapoptotic properties. In this study, we explored the underlying protective mechanisms of Ese decoction in isoproterenol (ISO)-induced cardiac fibrosis (CF) and established the fact that treatment with an Ese decoction attenuated tissue injury, decreased the release of IL-1 beta, IL-18, TNF-alpha, and caspase-3, and elevated the Bax/Bcl-2 ratio in CF mice. We also found that with Ese treatment damage to the mitochondrial ultrastructure of myocardium was alleviated, and the level of reactive oxygen species was markedly diminished. Ese inhibited the expression of proteins associated with pyroptosis by the HK1/NLRP3 signaling pathway and also improved CF. Due to the anti-inflammatory, antioxidative, and antiapoptotic characteristics of Ese decoction, we found that Ese protected against ISO-induced CF, by inhibiting inflammation and pyroptosis as mediated by the HK1/NLRP3 signaling pathway. Graphical Abstract Malus toringoides (Rehd.) Hughes decoction alleviates cardiac fibrosis by inhibiting cardiomyocyte inflammation and pyroptosis.
英文关键词	cardiac fibrosis; Eseye; anti-inflammation; pyroptosis
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Chemistry ; Food Science & Technology
WOS类目	Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Chemistry, Applied ; Food Science & Technology
WOS记录号	WOS:001232952900001
来源期刊	BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/293877
作者单位	Hebei Chemical & Pharmaceutical College; Hebei University of Chinese Medicine
推荐引用方式 GB/T 7714	Du, Huiru,Zhang, Yuling,Guo, Haochuan,et al. Malus toringoides (Rehd.) Hughes decoction alleviates isoproterenol-induced cardiac fibrosis by inhibiting cardiomyocyte inflammation and pyroptosis via the HK1/NLRP3 signaling pathway[J],2024.
APA	Du, Huiru.,Zhang, Yuling.,Guo, Haochuan.,Cheng, Xizhen.,Tian, Haolin.,...&Ma, Donglai.(2024).Malus toringoides (Rehd.) Hughes decoction alleviates isoproterenol-induced cardiac fibrosis by inhibiting cardiomyocyte inflammation and pyroptosis via the HK1/NLRP3 signaling pathway.BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY.
MLA	Du, Huiru,et al."Malus toringoides (Rehd.) Hughes decoction alleviates isoproterenol-induced cardiac fibrosis by inhibiting cardiomyocyte inflammation and pyroptosis via the HK1/NLRP3 signaling pathway".BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2024).