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| DOI | 10.1093/conphys/coae031 |
| Heat exposure limits pentose phosphate pathway activity in bumblebees | |
| 发表日期 | 2024 |
| ISSN | 2051-1434 |
| 起始页码 | 12 |
| 结束页码 | 1 |
| 卷号 | 12期号:1 |
| 英文摘要 | Bumblebee declines threaten pollination services worldwide. We explored the physiological mechanisms that may explain why bumblebees are susceptible to heat stress. We discovered that elevated temperatures limit the activity of the pentose phosphate pathway-a parallel pathway to glycolysis that generates antioxidant potential crucial for mitigating oxidative stress. Bumblebee populations across the globe are experiencing substantial declines due to climate change, with major consequences for pollination services in both natural and agricultural settings. Using an economically important species, Bombus impatiens, we explored the physiological mechanisms that may cause susceptibility to extreme heat events. We tested the hypothesis that heat exposure limits the activity of the pentose phosphate pathway (PPP)-a parallel pathway to glycolysis that can use nectar sugar to generate antioxidant potential and combat oxidative stress. Using isotopically labelled glucose, we tracked PPP activity in B. impatiens at rest, during exercise and during a post-exercise recovery period under two different temperature regimes (22 degrees C and 32 degrees C). We found that the PPP is routinely used by B. impatiens at moderate temperatures, but that its activity is markedly reduced when ATP demands are high, such as during periods of exercise and heat exposure. We also exposed B. impatiens to either 22 degrees C or 32 degrees C for 5 hours and assessed levels of oxidative damage (lipid peroxidation, protein carbonyls) and antioxidant potential [reduced (GSH) and oxidized (GSSG) glutathione concentrations]. Interestingly, bees exhibited little oxidative damage after the thermal exposure, but we found a lower GSH:GSSG ratio in 32 degrees C-exposed bees, reflecting lower antioxidant potential. Overall, our study demonstrates that acute heat stress severely limits PPP activity and may constrain antioxidant potential in B. impatiens. The repeated attenuation of this pathway in a warming climate may have more severe physiological consequences for this species, with potential implications for pollination services across North America. |
| 英文关键词 | Climate change; glucose; metabolic pathways; oxidative stress; pollinators; thermal stress |
| 语种 | 英语 |
| WOS研究方向 | Biodiversity & Conservation ; Environmental Sciences & Ecology ; Physiology |
| WOS类目 | Biodiversity Conservation ; Ecology ; Environmental Sciences ; Physiology |
| WOS记录号 | WOS:001233561500001 |
| 来源期刊 | CONSERVATION PHYSIOLOGY
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| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/291155 |
| 作者单位 | University of Toronto; University Toronto Scarborough; McMaster University |
| 推荐引用方式 GB/T 7714 | . Heat exposure limits pentose phosphate pathway activity in bumblebees[J],2024,12(1). |
| APA | (2024).Heat exposure limits pentose phosphate pathway activity in bumblebees.CONSERVATION PHYSIOLOGY,12(1). |
| MLA | "Heat exposure limits pentose phosphate pathway activity in bumblebees".CONSERVATION PHYSIOLOGY 12.1(2024). |
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