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| DOI | 10.1038/s42003-024-05818-1 |
| Establishment and characterization of turtle liver organoids provides a potential model to decode their unique adaptations | |
| 发表日期 | 2024 |
| EISSN | 2399-3642 |
| 起始页码 | 7 |
| 结束页码 | 1 |
| 卷号 | 7期号:1 |
| 英文摘要 | Painted turtles are remarkable for their freeze tolerance and supercooling ability along with their associated resilience to hypoxia/anoxia and oxidative stress, rendering them an ideal biomedical model for hypoxia-induced injuries (including strokes), tissue cooling during surgeries, and organ cryopreservation. Yet, such research is hindered by their seasonal reproduction and slow maturation. Here we developed and characterized adult stem cell-derived turtle liver organoids (3D self-assembled in vitro structures) from painted, snapping, and spiny softshell turtles spanning similar to 175My of evolution, with a subset cryopreserved. This development is, to the best of our knowledge, a first for this vertebrate Order, and complements the only other non-avian reptile organoids from snake venom glands. Preliminary characterization, including morphological, transcriptomic, and proteomic analyses, revealed organoids enriched in cholangiocytes. Deriving organoids from distant turtles and life stages demonstrates that our techniques are broadly applicable to chelonians, permitting the development of functional genomic tools currently lacking in herpetological research. Such platform could potentially support studies including genome-to-phenome mapping, gene function, genome architecture, and adaptive responses to climate change, with implications for ecological, evolutionary, and biomedical research. |
| 语种 | 英语 |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics |
| WOS类目 | Biology ; Multidisciplinary Sciences |
| WOS记录号 | WOS:001174673400002 |
| 来源期刊 | COMMUNICATIONS BIOLOGY
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/287724 |
| 作者单位 | Iowa State University; Iowa State University; Iowa State University; Iowa State University; University of Northern Iowa; H Lee Moffitt Cancer Center & Research Institute; Iowa State University; University of Texas System; University of Texas Rio Grande Valley; University of Iowa; University System of Georgia; University of Georgia |
| 推荐引用方式 GB/T 7714 | . Establishment and characterization of turtle liver organoids provides a potential model to decode their unique adaptations[J],2024,7(1). |
| APA | (2024).Establishment and characterization of turtle liver organoids provides a potential model to decode their unique adaptations.COMMUNICATIONS BIOLOGY,7(1). |
| MLA | "Establishment and characterization of turtle liver organoids provides a potential model to decode their unique adaptations".COMMUNICATIONS BIOLOGY 7.1(2024). |
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