气候变化领域集成服务门户(CCPortal): Transcriptome analysis reveals molecular pathways in the iron-overloaded Tibetan population

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	Transcriptome analysis reveals molecular pathways in the iron-overloaded Tibetan population
	Zhao, Qin; Hao, Doudou; Chen, Siyuan; Wang, Siyu; Zhou, Chaohua; Shi, Jing; Wan, Sha; Zhang, Yongqun; He, Zeng
发表日期	2023
ISSN	0918-8959
EISSN	1348-4540
起始页码	185
结束页码	196
卷号	70 期号:2
英文摘要	Iron overload can lead to chronic complications, serious organ dysfunction or death in the body. Under hypoxic conditions, the body needs more iron to produce red blood cells to adapt to the hypoxic environment. The prevalence of iron overload in the Tibetan population is higher than that in the Han population. To explore the molecular mechanism of iron -overload in the Tibetan population, this study investigated the transcriptome of the Tibetan iron overload population to obtain differentially expressed genes (DEGs) between the iron-overloaded population and the normal iron population. Functional enrichment analysis identified key related pathways, gene modules and coexpression networks under iron-overload conditions, and the 4 genes screened out have the potential to become target genes for studying the development of iron overload. A total of 28 pathways were screened to be closely related to the occurrence and development of iron overload, showing that iron overload is extremely related to erythrocyte homeostasis, cell cycle, oxidative phosphorylation, immunity, and transcriptional repression.
关键词	Transcriptome Tibetans Iron overload Functional enrichment analysis
英文关键词	INFLAMMATION; HOMEOSTASIS; CHROMIUM; FERRITIN; OBESITY; RATS
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:000938591600007
来源期刊	ENDOCRINE JOURNAL
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283786
推荐引用方式 GB/T 7714	Zhao, Qin,Hao, Doudou,Chen, Siyuan,et al. Transcriptome analysis reveals molecular pathways in the iron-overloaded Tibetan population[J],2023,70(2).
APA	Zhao, Qin.,Hao, Doudou.,Chen, Siyuan.,Wang, Siyu.,Zhou, Chaohua.,...&He, Zeng.(2023).Transcriptome analysis reveals molecular pathways in the iron-overloaded Tibetan population.ENDOCRINE JOURNAL,70(2).
MLA	Zhao, Qin,et al."Transcriptome analysis reveals molecular pathways in the iron-overloaded Tibetan population".ENDOCRINE JOURNAL 70.2(2023).