气候变化领域集成服务门户(CCPortal): Polymorphisms and mRNA Expression Levels of IGF-1, FGF5, and KAP 1.4 in Tibetan Cashmere Goats

CCPortal

DOI	10.3390/genes14030711
	Polymorphisms and mRNA Expression Levels of IGF-1, FGF5, and KAP 1.4 in Tibetan Cashmere Goats
	Song, Tianzeng; Tan, Yao; Cuomu, Renqing; Liu, Yacheng; Ba, Gui; Suo, Langda; Wu, Yujiang; Cao, Xiaohan; Zeng, Xianyin
发表日期	2023
EISSN	2073-4425
卷号	14 期号:3
英文摘要	The Tibetan cashmere goat is a precious breed in China and its cashmere is widely used in clothing and textiles. The genes IGF-1, FGF5, and KAP 1.4 have been shown to be crucial regulators of cashmere growth. In this study, we examined mRNA expression levels of these three genes and detected IGF-1, FGF5, and KAP 1.4 SNP loci in the Tibetan cashmere goat. After amplification and sequence alignment of the genes IGF-1, FGF5, and KAP 1.4 among 206 Tibetan cashmere goats, two new SNP loci were detected in gene KAP 1.4, while no SNP loci were found in amplified fragments of genes IGF-1 and FGF5. The expression levels of gene IGF-1 in Baingoin and Nyima counties were significantly higher than in other counties (p < 0.05). Moreover, the expression level of gene FGF5 in Gerze was significantly higher than in Rutog. The expression levels of mRNA in KAP 1.4 showed significant variation among seven counties. There were no significant differences in mRNA expression levels of IGF-1, FGF5, and KAP 1.4 in Tibetan cashmere goats when analysed by sex. The gene IGF-1 was slightly up-regulated in one to five-year-old cashmere goats, except in those that were 4 years old. The mRNA expression levels of FGF5 in one and two-year-old cashmere goats was lower compared with those in three to five-year-old cashmere goats. KAP 1.4 was up-regulated across one to five-year-old cashmere goats. In this study, SNP detection and mRNA expression analysis of IGF-1, FGF5, and KAP 1.4 genes was able to add data to genetic evolutionary analysis. Further studies should be carried out in SNPs to detect other fragments in genes IGF-1 and FGF5, as well as signal pathways and gene functions in protein levels of genes IGF-1, FGF5, and KAP 1.4 in the Tibetan cashmere goat.
关键词	mRNA expression SNP loci Tibetan cashmere goat
英文关键词	HAIR-GROWTH CYCLE; FACTOR-I GENE; TRAITS; SKIN; IDENTIFICATION; ASSOCIATION; REGULATOR; MUTATION
WOS研究方向	Genetics & Heredity
WOS记录号	WOS:000958602600001
来源期刊	GENES
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283654
作者单位	Tibet Academy of Agriculture & Animal Husbandry Sciences; Sichuan Agricultural University
推荐引用方式 GB/T 7714	Song, Tianzeng,Tan, Yao,Cuomu, Renqing,et al. Polymorphisms and mRNA Expression Levels of IGF-1, FGF5, and KAP 1.4 in Tibetan Cashmere Goats[J],2023,14(3).
APA	Song, Tianzeng.,Tan, Yao.,Cuomu, Renqing.,Liu, Yacheng.,Ba, Gui.,...&Zeng, Xianyin.(2023).Polymorphisms and mRNA Expression Levels of IGF-1, FGF5, and KAP 1.4 in Tibetan Cashmere Goats.GENES,14(3).
MLA	Song, Tianzeng,et al."Polymorphisms and mRNA Expression Levels of IGF-1, FGF5, and KAP 1.4 in Tibetan Cashmere Goats".GENES 14.3(2023).