气候变化领域集成服务门户(CCPortal): Evaluation of childhood developing via optical coherence tomography-angiography in Qamdo, Tibet, China: A prospective cross-sectional, school-based study

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DOI	10.12998/wjcc.v11.i23.5479
	Evaluation of childhood developing via optical coherence tomography-angiography in Qamdo, Tibet, China: A prospective cross-sectional, school-based study
	Sun, Ke-Xin; Xiang, Yong-Guo; Zhang, Tong; Yi, Sheng-Lan; Xia, Jiu-Yi; Yang, Xin; Zheng, Shi-Jie; Ji, Yan; Wan, Wen-Juan; Hu, Ke
发表日期	2023
ISSN	2307-8960
起始页码	5479
结束页码	5493
卷号	11 期号:23
英文摘要	BACKGROUND Optical coherence tomography angiography (OCTA) is a new and reliable machine used to evaluate retinal structure and macular perfusion in children. The use of OCTA under bad condition such as high altitude, low atmospheric oxygen, and low humidity, in children is rarely. AIM To quantify the macular micro-vasculature in healthy children of various ages using OCTA in Qamdo. METHODS Design: Prospective cross-sectional, school-based study. Three hundred and forty-seven normal students from 9 schools in 4 different areas in Qamdo were included. OCTA was performed on a 3 mm x 3 mm area centered on the macular region and macular cube 512 x 128 showed details in macular. Early treatment of diabetic retinopathy study Vessel Flow Density (VD) of the macular central vascular plexus density (CVD), inner vascular plexus density (IVD), full vascular plexus density (FVD), and the size of the foveal avascular zone (FAZ) were measured. All these results corrected by t/s = 3.382 x 0.01306 x (axial length-1.82). The differences were compared among various ages, sexes and living environments. RESULTS The mean FAZ area in all eyes was 0.27 mm(2) +/- 0.12 mm(2). The mean foveal thickness (MFT) in the macular cube was 227.64 mu m +/- 23.51 mu m. Compared with girls, boys had a lager FAZ (P = 0.0029). Among the different age groups, MFT (P < 0.001) and FVD (P < 0.0001), IVD (P < 0.0001), and CVD (P = 0.0050) increased with age. FAZ areas were not correlated with age (P = 0.8853) or others (MFT, area). CONCLUSION OCTA can use to evaluate macular perfusion in children. Our data bridge the gap between structural OCT and perfusion density in children in high altitude. Even though these were not a longitudinal study, it may provide us with hints about retina development during puberty and clinical implications of OCTA in children.
关键词	Optical coherence tomography-angiography Qamdo Foveal avascular zone area Vessel flow density Teenager
英文关键词	FOVEAL AVASCULAR ZONE; MACULAR VESSEL DENSITY; RETINAL MICROVASCULATURE; CHILDREN; AGE; MICROCIRCULATION; CHORIOCAPILLARIS; PERIPAPILLARY; RETINOPATHY; THICKNESS
WOS研究方向	Medicine, General & Internal
WOS记录号	WOS:001054089300008
来源期刊	WORLD JOURNAL OF CLINICAL CASES
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283514
作者单位	Chongqing Medical University; Chongqing Medical University
推荐引用方式 GB/T 7714	Sun, Ke-Xin,Xiang, Yong-Guo,Zhang, Tong,et al. Evaluation of childhood developing via optical coherence tomography-angiography in Qamdo, Tibet, China: A prospective cross-sectional, school-based study[J],2023,11(23).
APA	Sun, Ke-Xin.,Xiang, Yong-Guo.,Zhang, Tong.,Yi, Sheng-Lan.,Xia, Jiu-Yi.,...&Hu, Ke.(2023).Evaluation of childhood developing via optical coherence tomography-angiography in Qamdo, Tibet, China: A prospective cross-sectional, school-based study.WORLD JOURNAL OF CLINICAL CASES,11(23).
MLA	Sun, Ke-Xin,et al."Evaluation of childhood developing via optical coherence tomography-angiography in Qamdo, Tibet, China: A prospective cross-sectional, school-based study".WORLD JOURNAL OF CLINICAL CASES 11.23(2023).