气候变化领域集成服务门户(CCPortal): Exposure of Tibetan pregnant women to antibiotics in China: A biomonitoring-based study

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DOI	10.1016/j.envpol.2023.121439
	Exposure of Tibetan pregnant women to antibiotics in China: A biomonitoring-based study
	Wang, Yuanping; Chen, Yue; Gesang, Yangzong; Yang, Zichen; Wang, Yi; Zhao, Ke; Han, Minghui; Li, Chunxia; Ouzhu, Luobu; Wang, Jiwei; Wang, Hexing; Jiang, Qingwu
发表日期	2023
ISSN	0269-7491
EISSN	1873-6424
卷号	325
英文摘要	Tibetan people are one Chinese ethnic minority living in Qinghai-Tibet Plateau with an average altitude of more than 4500 m. High altitude could cause a different antibiotic exposure, but relevant information is limited in Tibetan people. We investigated 476 Tibetan pregnant women in Lhasa, Tibet in 2021 and measured 30 anti-biotics from five categories in urine, including 13 veterinary antibiotics (VAs), five human antibiotics (HAs), and 12 human/veterinary antibiotics (H/VAs). Food consumption was investigated by a brief food frequency ques-tionnaire. Health risk was assessed by hazard quotient (HQ) and hazard index (HI) based on acceptable daily intakes (ADIs). All antibiotics were overall detected in 34.7% of urine samples with the 75th percentile con-centration of 0.19 ng/mL (0.35 mu g/g creatinine). HAs, VAs, and H/VAs were respectively detected in 5.3%, 13.0%, and 25.0% of urine samples, with the 95th percentiles of 0.01 ng/mL (0.01 mu g/g creatinine), 0.50 ng/mL (0.99 mu g/g creatinine), and 3.58 ng/mL (5.02 mu g/g creatinine), respectively. Maternal age, smoking of family members, and housework time were associated with detection frequencies of HAs, VAs, or sum of all antibiotics. Pregnant women with a more frequent consumption of fresh milk, egg, yoghourt, poultry meat, and fish had a higher detection frequency of VAs or H/VAs. Only ciprofloxacin and tetracycline had a HQ of larger than one based on microbiological effect in 1.26% and 0.21% of pregnant women, respectively and a HI of larger than one was found in 1.47% of pregnant women. The findings suggested that there was an evident antibiotic exposure from various sources in Tibetan pregnant women with some basic characteristics of pregnant women as potential predictors and several animal-derived food items were important sources of exposure to antibiotic with a fraction of pregnant women in the health risk related to microbiological disruption of gut microbiota.
关键词	Tibet Pregnant women Antibiotic Urine Source Health risk
英文关键词	HUMAN HEALTH-RISK; URINARY ANTIBIOTICS; WATER; PHARMACEUTICALS; PRODUCTS; SHANGHAI; CHILDREN; SHIGATSE; DISEASE; BURDEN
WOS研究方向	Environmental Sciences
WOS记录号	WOS:000957667200001
来源期刊	ENVIRONMENTAL POLLUTION
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283110
作者单位	Fudan University; University of Ottawa; Tibet University; Tibet University
推荐引用方式 GB/T 7714	Wang, Yuanping,Chen, Yue,Gesang, Yangzong,et al. Exposure of Tibetan pregnant women to antibiotics in China: A biomonitoring-based study[J],2023,325.
APA	Wang, Yuanping.,Chen, Yue.,Gesang, Yangzong.,Yang, Zichen.,Wang, Yi.,...&Jiang, Qingwu.(2023).Exposure of Tibetan pregnant women to antibiotics in China: A biomonitoring-based study.ENVIRONMENTAL POLLUTION,325.
MLA	Wang, Yuanping,et al."Exposure of Tibetan pregnant women to antibiotics in China: A biomonitoring-based study".ENVIRONMENTAL POLLUTION 325(2023).