气候变化领域集成服务门户(CCPortal): Four-year analysis of high-risk human papillomavirus infection among women in rural areas of Nyingchi City, Tibet

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DOI	10.3389/fpubh.2023.1251440
	Four-year analysis of high-risk human papillomavirus infection among women in rural areas of Nyingchi City, Tibet
	Li, Jianqi; Li, Xiaojie; Sheng, Xiujie
发表日期	2023
EISSN	2296-2565
卷号	11
英文摘要	Purpose: This study aims to address the existing data gap regarding the status of high-risk human papillomavirus (HR-HPV) infection and the distribution of HR-HPV subtypes among women in rural areas of Nyingchi City, Tibet. The research objectives include providing insights for HPV vaccine development.Methods: The research collected data from two rounds of cancer screening conducted among rural women in Nyingchi City, Tibet, from 2019 to 2022. HR-HPV subtype gene detection was performed using the PCR fluorescence method on the collected samples. And then analyzed the HR-HPV infection rate among rural women in Nyingchi City, Tibet, as well as the infection rate of different HR-HPV subtypes and their distribution across different age groups. A comparison was made between the infection rates of women in rural areas outside the Qinghai-Tibet Plateau and those in Nyingchi City.Results: A total of 15,687 cases included. The overall HR-HPV infection rate among women in rural areas of Nyingchi City, Tibet, was 13.00% (2040/15,687), which was significantly higher than the rate among women in rural areas outside the Qinghai-Tibet Plateau (7.82% (9,249/118,237); chi(2) = 635.7, p < 0.001). The highest HPV infection rate was observed in the 35-39 age group, with a rate of 15.31% (499/3260), which was significantly higher than the rate of 7.22% (1827/25,322) among women in the same age group in rural areas outside the Qinghai-Tibet Plateau (chi(2) = 253.00, p < 0.001). The lowest HPV infection rate was found in the 50-54 age group, with a rate of 9.69% (246/2540), which was statistically different from the rate of 8.14% (1,604/19,698) among women in the same age group outside the Qinghai-Tibet Plateau (chi(2) = 17.68, p < 0.001). The top three HR-HPV subtypes among women in rural areas of Nyingchi City, Tibet, were HPV52 (20.15%, 411/2040), HPV16 (12.45%, 254/2040), and HPV58 (11.96%, 244/2040). These findings align with the top three HR-HPV subtypes among women in rural areas outside the Qinghai-Tibet Plateau. Furthermore, the top three HR-HPV subtypes among women aged 35-39, 40-44, and 45-49 in rural areas of Nyingchi City, Tibet, were HPV52, HPV16, and HPV58. In conclusion, the HR-HPV infection rate among women in rural areas of Nyingchi City, Tibet, is significantly higher compared to women in rural areas outside the Qinghai-Tibet Plateau, with consistent patterns observed in the distribution of the top three HR-HPV subtypes between the two regions.
关键词	HR-HPV HR-HPV subtypes rural women Qinghai-Tibet plateau Tibet (China)
英文关键词	GENOTYPE DISTRIBUTION; PREVALENCE; CHINA; AGE; PROVINCE; CYTOLOGY
WOS研究方向	Public, Environmental & Occupational Health
WOS记录号	WOS:001077116200001
来源期刊	FRONTIERS IN PUBLIC HEALTH
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/282560
作者单位	Guangzhou Medical University
推荐引用方式 GB/T 7714	Li, Jianqi,Li, Xiaojie,Sheng, Xiujie. Four-year analysis of high-risk human papillomavirus infection among women in rural areas of Nyingchi City, Tibet[J],2023,11.
APA	Li, Jianqi,Li, Xiaojie,&Sheng, Xiujie.(2023).Four-year analysis of high-risk human papillomavirus infection among women in rural areas of Nyingchi City, Tibet.FRONTIERS IN PUBLIC HEALTH,11.
MLA	Li, Jianqi,et al."Four-year analysis of high-risk human papillomavirus infection among women in rural areas of Nyingchi City, Tibet".FRONTIERS IN PUBLIC HEALTH 11(2023).