气候变化领域集成服务门户(CCPortal): The contribution of the exposome to the burden of cardiovascular disease

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DOI	10.1038/s41569-023-00873-3
	The contribution of the exposome to the burden of cardiovascular disease
	Muenzel, Thomas; Sorensen, Mette; Hahad, Omar; Nieuwenhuijsen, Mark; Daiber, Andreas
发表日期	2023
ISSN	1759-5002
EISSN	1759-5010
起始页码	651
结束页码	669
卷号	20 期号:10
英文摘要	Large epidemiological and health impact assessment studies at the global scale, such as the Global Burden of Disease project, indicate that chronic non-communicable diseases, such as atherosclerosis and diabetes mellitus, caused almost two-thirds of the annual global deaths in 2020. By 2030, 77% of all deaths are expected to be caused by non-communicable diseases. Although this increase is mainly due to the ageing of the general population in Western societies, other reasons include the increasing effects of soil, water, air and noise pollution on health, together with the effects of other environmental risk factors such as climate change, unhealthy city designs (including lack of green spaces), unhealthy lifestyle habits and psychosocial stress. The exposome concept was established in 2005 as a new strategy to study the effect of the environment on health. The exposome describes the harmful biochemical and metabolic changes that occur in our body owing to the totality of different environmental exposures throughout the life course, which ultimately lead to adverse health effects and premature deaths. In this Review, we describe the exposome concept with a focus on environmental physical and chemical exposures and their effects on the burden of cardiovascular disease. We discuss selected exposome studies and highlight the relevance of the exposome concept for future health research as well as preventive medicine. We also discuss the challenges and limitations of exposome studies. In this Review, Munzel and colleagues describe the exposome concept with a focus on environmental physical and chemical exposures and their effects on the burden of cardiovascular disease. Additionally, they discuss selected exposome studies and the relevance of the exposome concept for future health research and preventive medicine.
语种	英语
WOS研究方向	Cardiac & Cardiovascular Systems
WOS类目	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000985220800001
来源期刊	NATURE REVIEWS CARDIOLOGY
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/281456
作者单位	Johannes Gutenberg University of Mainz; German Centre for Cardiovascular Research; Danish Cancer Society; Roskilde University; ISGlobal; Pompeu Fabra University; Pompeu Fabra University; Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBERESP
推荐引用方式 GB/T 7714	Muenzel, Thomas,Sorensen, Mette,Hahad, Omar,et al. The contribution of the exposome to the burden of cardiovascular disease[J],2023,20(10).
APA	Muenzel, Thomas,Sorensen, Mette,Hahad, Omar,Nieuwenhuijsen, Mark,&Daiber, Andreas.(2023).The contribution of the exposome to the burden of cardiovascular disease.NATURE REVIEWS CARDIOLOGY,20(10).
MLA	Muenzel, Thomas,et al."The contribution of the exposome to the burden of cardiovascular disease".NATURE REVIEWS CARDIOLOGY 20.10(2023).