气候变化领域集成服务门户(CCPortal): Pangenomic analysis identifies structural variation associated with heat tolerance in pearl millet

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DOI	10.1038/s41588-023-01302-4
	Pangenomic analysis identifies structural variation associated with heat tolerance in pearl millet
	Yan, Haidong; Sun, Min; Zhang, Zhongren; Jin, Yarong; Zhang, Ailing; Lin, Chuang; Wu, Bingchao; He, Min; Xu, Bin; Wang, Jing; Qin, Peng; Mendieta, John Pablo; Nie, Gang; Wang, Jianping; Jones, Chris S. S.; Feng, Guangyan; Srivastava, Rakesh K. K.; Zhang, Xinquan; Bombarely, Aureliano; Luo, Dan; Jin, Long; Peng, Yuanying; Wang, Xiaoshan; Ji, Yang; Tian, Shilin; Huang, Linkai
发表日期	2023
ISSN	1061-4036
EISSN	1546-1718
起始页码	507
结束页码	+
卷号	55 期号:3
英文摘要	Pearl millet is an important cereal crop worldwide and shows superior heat tolerance. Here, we developed a graph-based pan-genome by assembling ten chromosomal genomes with one existing assembly adapted to different climates worldwide and captured 424,085 genomic structural variations (SVs). Comparative genomics and transcriptomics analyses revealed the expansion of the RWP-RK transcription factor family and the involvement of endoplasmic reticulum (ER)-related genes in heat tolerance. The overexpression of one RWP-RK gene led to enhanced plant heat tolerance and transactivated ER-related genes quickly, supporting the important roles of RWP-RK transcription factors and ER system in heat tolerance. Furthermore, we found that some SVs affected the gene expression associated with heat tolerance and SVs surrounding ER-related genes shaped adaptation to heat tolerance during domestication in the population. Our study provides a comprehensive genomic resource revealing insights into heat tolerance and laying a foundation for generating more robust crops under the changing climate. A graph-based pan-genome constructed using de novo genome assemblies of ten pearl millet accessions adapted to different climates worldwide identifies structural variations and their contribution to heat tolerance in pearl millet.
语种	英语
WOS研究方向	Genetics & Heredity
WOS类目	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000971784400002
来源期刊	NATURE GENETICS
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/281256
作者单位	Sichuan Agricultural University; Virginia Polytechnic Institute & State University; University System of Georgia; University of Georgia; Sichuan Agricultural University; Nanjing Agricultural University; Sichuan University; Sichuan Agricultural University; State University System of Florida; University of Florida; CGIAR; International Livestock Research Institute (ILRI); CGIAR; International Crops Research Institute for the Semi-Arid-Tropics (ICRISAT); Consejo Superior de Investigaciones Cientificas (CSIC); Sichuan Agricultural University; Sichuan Agricultural University; Sichuan Academy of Agricultural Sciences (SAAS); Wuhan University
推荐引用方式 GB/T 7714	Yan, Haidong,Sun, Min,Zhang, Zhongren,et al. Pangenomic analysis identifies structural variation associated with heat tolerance in pearl millet[J],2023,55(3).
APA	Yan, Haidong.,Sun, Min.,Zhang, Zhongren.,Jin, Yarong.,Zhang, Ailing.,...&Huang, Linkai.(2023).Pangenomic analysis identifies structural variation associated with heat tolerance in pearl millet.NATURE GENETICS,55(3).
MLA	Yan, Haidong,et al."Pangenomic analysis identifies structural variation associated with heat tolerance in pearl millet".NATURE GENETICS 55.3(2023).