气候变化领域集成服务门户(CCPortal): Natural selection for imprecise vertical transmission in host

CCPortal

DOI	10.1038/s41559-021-01593-y
	Natural selection for imprecise vertical transmission in host–microbiota systems
	Bruijning M.; Henry L.P.; Forsberg S.K.G.; Metcalf C.J.E.; Ayroles J.F.
发表日期	2022
ISSN	2397-334X
起始页码	77
结束页码	87
卷号	6 期号:1
英文摘要	How and when the microbiome modulates host adaptation remains an evolutionary puzzle, despite evidence that the extended genetic repertoire of the microbiome can shape host phenotypes and fitness. One complicating factor is that the microbiome is often transmitted imperfectly across host generations, leading to questions about the degree to which the microbiome contributes to host adaptation. Here, using an evolutionary model, we demonstrate that decreasing vertical transmission fidelity can increase microbiome variation, and thus phenotypic variation, across hosts. When the most beneficial microbial genotypes change unpredictably from one generation to the next (for example, in variable environments), hosts can maximize fitness by increasing the microbiome variation among offspring, as this improves the chance of there being an offspring with the right microbial combination for the next generation. Imperfect vertical transmission can therefore be adaptive in varying environments. We characterize how selection on vertical transmission is shaped by environmental conditions, microbiome changes during host development and the contribution of other factors to trait variation. We illustrate how environmentally dependent microbial effects can favour intermediate transmission and set our results in the context of examples from natural systems. We also suggest research avenues to empirically test our predictions. Our model provides a basis to understand the evolutionary pathways that potentially led to the wide diversity of microbe transmission patterns found in nature. ? 2021, The Author(s), under exclusive licence to Springer Nature Limited.
语种	英语
scopus关键词	evolution; genetic selection; genetics; microflora; phenotype; Biological Evolution; Microbiota; Phenotype; Selection, Genetic
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257221
作者单位	Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, United States; Lewis-Sigler Institute for Integrative Genomics, Princeton, NJ, United States
推荐引用方式 GB/T 7714	Bruijning M.,Henry L.P.,Forsberg S.K.G.,等. Natural selection for imprecise vertical transmission in host–microbiota systems[J],2022,6(1).
APA	Bruijning M.,Henry L.P.,Forsberg S.K.G.,Metcalf C.J.E.,&Ayroles J.F..(2022).Natural selection for imprecise vertical transmission in host–microbiota systems.Nature Ecology & Evolution,6(1).
MLA	Bruijning M.,et al."Natural selection for imprecise vertical transmission in host–microbiota systems".Nature Ecology & Evolution 6.1(2022).