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DOI	10.1038/s41559-021-01591-0
	Prochlorococcus have low global mutation rate and small effective population size
	Chen Z.; Wang X.; Song Y.; Zeng Q.; Zhang Y.; Luo H.
发表日期	2022
ISSN	2397-334X
起始页码	183
结束页码	194
卷号	6 期号:2
英文摘要	Prochlorococcus are the most abundant free-living photosynthetic carbon-fixing organisms in the ocean. Prochlorococcus show small genome sizes, low genomic G+C content, reduced DNA repair gene pool and fast evolutionary rates, which are typical features of endosymbiotic bacteria. Nevertheless, their evolutionary mechanisms are believed to be different. Evolution of endosymbiotic bacteria is dominated by genetic drift owing to repeated population bottlenecks, whereas Prochlorococcus are postulated to have extremely large effective population sizes (Ne) and thus drift has rarely been considered. However, accurately extrapolating Ne requires measuring an unbiased global mutation rate through mutation accumulation, which is challenging for Prochlorococcus. Here, we managed this experiment over 1,065 days using Prochlorococcus marinus AS9601, sequenced genomes of 141 mutant lines and determined its mutation rate to be 3.50 × 10?10 per site per generation. Extrapolating Ne additionally requires identifying population boundaries, which we defined using PopCOGenT and over 400 genomes related to AS9601. Accordingly, we calculated its Ne to be 1.68 × 107, which is only reasonably greater than that of endosymbiotic bacteria but surprisingly smaller than that of many free-living bacteria extrapolated using the same approach. Our results therefore suggest that genetic drift is a key driver of Prochlorococcus evolution. ? 2021, The Author(s), under exclusive licence to Springer Nature Limited.
语种	英语
scopus关键词	bacterial genome; genetics; molecular evolution; mutation rate; population density; Prochlorococcus; Evolution, Molecular; Genome, Bacterial; Mutation Rate; Population Density; Prochlorococcus
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257149
作者单位	State Key Laboratory of Marine Environmental Science and College of Ocean and Earth Sciences, Xiamen University, Xiamen, China; Simon F. S. Li Marine Science Laboratory, School of Life Sciences and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, Hong Kong; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China; Department of Ocean Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong; Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Clear Water Bay, Hong Kong
推荐引用方式 GB/T 7714	Chen Z.,Wang X.,Song Y.,et al. Prochlorococcus have low global mutation rate and small effective population size[J],2022,6(2).
APA	Chen Z.,Wang X.,Song Y.,Zeng Q.,Zhang Y.,&Luo H..(2022).Prochlorococcus have low global mutation rate and small effective population size.Nature Ecology & Evolution,6(2).
MLA	Chen Z.,et al."Prochlorococcus have low global mutation rate and small effective population size".Nature Ecology & Evolution 6.2(2022).