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DOI	10.1038/s41559-022-01671-9
	Domestication reprogrammed the budding yeast life cycle
	De Chiara M.; Barré B.P.; Persson K.; Irizar A.; Vischioni C.; Khaiwal S.; Stenberg S.; Amadi O.C.; ?un G.; Dober?ek K.; Taccioli C.; Schacherer J.; Petrovi? U.; Warringer J.; Liti G.
发表日期	2022
ISSN	2397-334X
起始页码	448
结束页码	460
卷号	6 期号:4
英文摘要	Domestication of plants and animals is the foundation for feeding the world human population but can profoundly alter the biology of the domesticated species. Here we investigated the effect of domestication on one of our prime model organisms, the yeast Saccharomyces cerevisiae, at a species-wide level. We tracked the capacity for sexual and asexual reproduction and the chronological life span across a global collection of 1,011 genome-sequenced yeast isolates and found a remarkable dichotomy between domesticated and wild strains. Domestication had systematically enhanced fermentative and reduced respiratory asexual growth, altered the tolerance to many stresses and abolished or impaired the sexual life cycle. The chronological life span remained largely unaffected by domestication and was instead dictated by clade-specific evolution. We traced the genetic origins of the yeast domestication syndrome using genome-wide association analysis and genetic engineering and disclosed causative effects of aneuploidy, gene presence/absence variations, copy number variations and single-nucleotide polymorphisms. Overall, we propose domestication to be the most dramatic event in budding yeast evolution, raising questions about how much domestication has distorted our understanding of the natural biology of this key model species. ? 2022, The Author(s), under exclusive licence to Springer Nature Limited.
语种	英语
scopus关键词	animal; budding yeast; copy number variation; domestication; genetics; genome-wide association study; life cycle stage; Saccharomyces cerevisiae; Animals; DNA Copy Number Variations; Domestication; Genome-Wide Association Study; Life Cycle Stages; Saccharomyces cerevisiae; Saccharomycetales
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257107
作者单位	Université C?te d’Azur, CNRS, INSERM, IRCAN, Nice, France; Department of Chemistry and Molecular Biology, Gothenburg University, Gothenburg, Sweden; Department of Animal Medicine, Production and Health, University of Padova, Legnaro, Italy; Department of Microbiology, University of Nigeria, Nsukka, Nigeria; Department of Molecular and Biomedical Sciences, Jo?ef Stefan Institute, Ljubljana, Slovenia; Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia; Université de Strasbourg, CNRS, GMGM UMR, Strasbourg, France; Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States
推荐引用方式 GB/T 7714	De Chiara M.,Barré B.P.,Persson K.,et al. Domestication reprogrammed the budding yeast life cycle[J],2022,6(4).
APA	De Chiara M..,Barré B.P..,Persson K..,Irizar A..,Vischioni C..,...&Liti G..(2022).Domestication reprogrammed the budding yeast life cycle.Nature Ecology & Evolution,6(4).
MLA	De Chiara M.,et al."Domestication reprogrammed the budding yeast life cycle".Nature Ecology & Evolution 6.4(2022).