气候变化领域集成服务门户(CCPortal): Timing the origin of eukaryotic cellular complexity with ancient duplications

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DOI	10.1038/s41559-020-01320-z
	Timing the origin of eukaryotic cellular complexity with ancient duplications
	Vosseberg J.; van Hooff J.J.E.; Marcet-Houben M.; van Vlimmeren A.; van Wijk L.M.; Gabaldón T.; Snel B.
发表日期	2021
ISSN	2397-334X
起始页码	92
结束页码	100
卷号	5 期号:1
英文摘要	Eukaryogenesis is one of the most enigmatic evolutionary transitions, during which simple prokaryotic cells gave rise to complex eukaryotic cells. While evolutionary intermediates are lacking, gene duplications provide information on the order of events by which eukaryotes originated. Here we use a phylogenomics approach to reconstruct successive steps during eukaryogenesis. We find that gene duplications roughly doubled the proto-eukaryotic gene repertoire, with families inherited from the Asgard archaea-related host being duplicated most. By relatively timing events using phylogenetic distances, we inferred that duplications in cytoskeletal and membrane-trafficking families were among the earliest events, whereas most other families expanded predominantly after mitochondrial endosymbiosis. Altogether, we infer that the host that engulfed the proto-mitochondrion had some eukaryote-like complexity, which drastically increased upon mitochondrial acquisition. This scenario bridges the signs of complexity observed in Asgard archaeal genomes to the proposed role of mitochondria in triggering eukaryogenesis. ? 2020, The Author(s), under exclusive licence to Springer Nature Limited.
语种	英语
scopus关键词	archaeon; eukaryote; eukaryotic cell; evolution; genetics; human; phylogeny; Archaea; Biological Evolution; Eukaryota; Eukaryotic Cells; Humans; Phylogeny
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257056
作者单位	Theoretical Biology and Bioinformatics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, Netherlands; Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain; Life Sciences Department, Barcelona Supercomputing Center, Barcelona, Spain; Mechanisms of Disease, Institute for Research in Biomedicine, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avan?ats, Barcelona, Spain; Ecologie Systématique Evolution, CNRS, Université Paris-Saclay, AgroParisTech, Orsay, France; Department of Biological Sciences, Columbia University, New York City, NY, United States
推荐引用方式 GB/T 7714	Vosseberg J.,van Hooff J.J.E.,Marcet-Houben M.,et al. Timing the origin of eukaryotic cellular complexity with ancient duplications[J],2021,5(1).
APA	Vosseberg J..,van Hooff J.J.E..,Marcet-Houben M..,van Vlimmeren A..,van Wijk L.M..,...&Snel B..(2021).Timing the origin of eukaryotic cellular complexity with ancient duplications.Nature Ecology & Evolution,5(1).
MLA	Vosseberg J.,et al."Timing the origin of eukaryotic cellular complexity with ancient duplications".Nature Ecology & Evolution 5.1(2021).