气候变化领域集成服务门户(CCPortal): Conservative route to genome compaction in a miniature annelid

CCPortal

DOI	10.1038/s41559-020-01327-6
	Conservative route to genome compaction in a miniature annelid
	Martín-Durán J.M.; Vellutini B.C.; Marlétaz F.; Cetrangolo V.; Cvetesic N.; Thiel D.; Henriet S.; Grau-Bové X.; Carrillo-Baltodano A.M.; Gu W.; Kerbl A.; Marquez Y.; Bekkouche N.; Chourrout D.; Gómez-Skarmeta J.L.; Irimia M.; Lenhard B.; Worsaae K.; Hejnol A.
发表日期	2021
ISSN	2397-334X
起始页码	231
结束页码	242
卷号	5 期号:2
英文摘要	The causes and consequences of genome reduction in animals are unclear because our understanding of this process mostly relies on lineages with often exceptionally high rates of evolution. Here, we decode the compact 73.8-megabase genome of Dimorphilus gyrociliatus, a meiobenthic segmented worm. The D. gyrociliatus genome retains traits classically associated with larger and slower-evolving genomes, such as an ordered, intact Hox cluster, a generally conserved developmental toolkit and traces of ancestral bilaterian linkage. Unlike some other animals with small genomes, the analysis of the D. gyrociliatus epigenome revealed canonical features of genome regulation, excluding the presence of operons and trans-splicing. Instead, the gene-dense D. gyrociliatus genome presents a divergent Myc pathway, a key physiological regulator of growth, proliferation and genome stability in animals. Altogether, our results uncover a conservative route to genome compaction in annelids, reminiscent of that observed in the vertebrate Takifugu rubripes. ? 2020, The Author(s).
语种	英语
scopus关键词	animal; annelid; genetic linkage; genetics; genome; molecular evolution; Takifugu; Animals; Annelida; Evolution, Molecular; Genetic Linkage; Genome; Takifugu
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257034
作者单位	Sars International Centre for Marine Molecular Biology, University of Bergen, Bergen, Norway; School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany; Molecular Genetics Unit, Okinawa Institute of Science and Technology, Graduate University, Onna, Japan; Department of Biological Sciences, University of Bergen, Bergen, Norway; Institute for Clinical Sciences and MRC London Institute of Medical Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom; Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Department of Biology, University of Copenhagen, Copenhagen, Denmark; Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain; Centro Andaluz de Biología del Desarrollo, Consejo Superior de Investigaciones Cientificas-Universidad Pablo de Olavide-Junta de Andalucía, Seville, Spain; Uni...
推荐引用方式 GB/T 7714	Martín-Durán J.M.,Vellutini B.C.,Marlétaz F.,et al. Conservative route to genome compaction in a miniature annelid[J],2021,5(2).
APA	Martín-Durán J.M..,Vellutini B.C..,Marlétaz F..,Cetrangolo V..,Cvetesic N..,...&Hejnol A..(2021).Conservative route to genome compaction in a miniature annelid.Nature Ecology & Evolution,5(2).
MLA	Martín-Durán J.M.,et al."Conservative route to genome compaction in a miniature annelid".Nature Ecology & Evolution 5.2(2021).