气候变化领域集成服务门户(CCPortal): Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases

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DOI	10.1038/s41559-020-01355-2
	Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases
	Pavard S.; Coste C.F.D.
发表日期	2021
ISSN	2397-334X
起始页码	392
结束页码	400
卷号	5 期号:3
英文摘要	Assessing the role played by purifying selection on a susceptibility allele to late-onset disease (SALOD) is crucial to understanding the puzzling allelic spectrum of a disease, because most alleles are recent and rare. This fact is surprising because it suggests that alleles are under purifying selection while those that are involved in post-menopause mortality are often considered neutral in the genetic literature. The aim of this article is to use an evolutionary demography model to assess the magnitude of selection on SALODs while accounting for epidemiological and sociocultural factors. We develop an age-structured population model allowing for the calculation of SALOD selection coefficients (1) for a large and realistic parameter space for disease onset, (2) in a two-sex model in which men can reproduce in old age and (3) for situations in which child survival depends on maternal, paternal and grandmaternal care. The results show that SALODs are under purifying selection for most known age-at-onset distributions of late-onset genetic diseases. Estimates regarding various genes involved in susceptibility to cancer or Huntington’s disease demonstrate that negative selection largely overcomes the effects of drift in most human populations. This is also probably true for neurodegenerative or polycystic kidney diseases, although sociocultural factors modulate the effect of selection in these cases. We conclude that neutrality is probably the exception among alleles that have a deleterious effect in old age and that accounting for sociocultural factors is required to understand the full extent of the force of selection shaping senescence in humans. ? 2021, The Author(s), under exclusive licence to Springer Nature Limited.
语种	英语
scopus关键词	allele; child; demography; evolution; female; human; Alleles; Biological Evolution; Child; Demography; Female; Humans
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257019
作者单位	Unité 7206 Eco-anthropologie, Muséum National d’Histoire Naturelle, CNRS, Université de Paris, Paris, France; Department of Biology, Centre for Biodiversity Dynamics, Norwegian University of Science and Technology, Trondheim, Norway
推荐引用方式 GB/T 7714	Pavard S.,Coste C.F.D.. Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases[J],2021,5(3).
APA	Pavard S.,&Coste C.F.D..(2021).Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases.Nature Ecology & Evolution,5(3).
MLA	Pavard S.,et al."Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases".Nature Ecology & Evolution 5.3(2021).