气候变化领域集成服务门户(CCPortal): Host diversity slows bacteriophage adaptation by selecting generalists over specialists

CCPortal

DOI	10.1038/s41559-020-01364-1
	Host diversity slows bacteriophage adaptation by selecting generalists over specialists
	Sant D.G.; Woods L.C.; Barr J.J.; McDonald M.J.
发表日期	2021
ISSN	2397-334X
起始页码	350
结束页码	359
卷号	5 期号:3
英文摘要	Most viruses can infect multiple hosts, yet the selective mechanisms that maintain multi-host generalists over single-host specialists remain an open question. Here we propagate populations of the newly identified bacteriophage ?JB01 in coculture with many host genotypes and find that while phage can adapt to infect any of the new hosts, increasing the number of hosts slows the rate of adaptation. We quantify trade-offs in the capacity for individual phage to infect different hosts and find that phage from evolved populations with more hosts are more likely to be generalists. Sequencing of evolved phage reveals strong selection and the genetic basis of adaptation, supporting a model that shows how the addition of more potential hosts to a community can select for low-fitness generalists over high-fitness specialists. Our results show how evolution with multiple hosts alters the rate of viral adaptation and provides empirical support for an evolutionary mechanism that promotes generalists over specialists. ? 2021, The Author(s), under exclusive licence to Springer Nature Limited.
语种	英语
scopus关键词	acclimatization; adaptation; bacteriophage; genetics; genotype; specialization; Acclimatization; Adaptation, Physiological; Bacteriophages; Genotype; Specialization
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/257009
作者单位	School of Biological Sciences, Monash University, Monash, VIC, Australia
推荐引用方式 GB/T 7714	Sant D.G.,Woods L.C.,Barr J.J.,et al. Host diversity slows bacteriophage adaptation by selecting generalists over specialists[J],2021,5(3).
APA	Sant D.G.,Woods L.C.,Barr J.J.,&McDonald M.J..(2021).Host diversity slows bacteriophage adaptation by selecting generalists over specialists.Nature Ecology & Evolution,5(3).
MLA	Sant D.G.,et al."Host diversity slows bacteriophage adaptation by selecting generalists over specialists".Nature Ecology & Evolution 5.3(2021).