气候变化领域集成服务门户(CCPortal): The functional genetic architecture of egg-laying and live-bearing reproduction in common lizards

CCPortal

DOI	10.1038/s41559-021-01555-4
	The functional genetic architecture of egg-laying and live-bearing reproduction in common lizards
	Recknagel H.; Carruthers M.; Yurchenko A.A.; Nokhbatolfoghahai M.; Kamenos N.A.; Bain M.M.; Elmer K.R.
发表日期	2021
ISSN	2397-334X
起始页码	1546
结束页码	1556
卷号	5 期号:11
英文摘要	All amniotes reproduce either by egg-laying (oviparity), which is ancestral to vertebrates or by live-bearing (viviparity), which has evolved many times independently. However, the genetic basis of these parity modes has never been resolved and, consequently, its convergence across evolutionary scales is currently unknown. Here, we leveraged natural hybridizations between oviparous and viviparous common lizards (Zootoca vivipara) to describe the functional genes and genetic architecture of parity mode and its key traits, eggshell and gestation length, and compared our findings across vertebrates. In these lizards, parity trait genes were associated with progesterone-binding functions and enriched for tissue remodelling and immune system pathways. Viviparity involved more genes and complex gene networks than did oviparity. Angiogenesis, vascular endothelial growth and adrenoreceptor pathways were enriched in the viviparous female reproductive tissue, while pathways for transforming growth factor were enriched in the oviparous. Natural selection on these parity mode genes was evident genome-wide. Our comparison to seven independent origins of viviparity in mammals, squamates and fish showed that genes active in pregnancy were related to immunity, tissue remodelling and blood vessel generation. Therefore, our results suggest that pre-established regulatory networks are repeatedly recruited for viviparity and that these are shared at deep evolutionary scales. ? 2021, The Author(s), under exclusive licence to Springer Nature Limited.
语种	英语
scopus关键词	animal; female; genetics; lizard; oviparity; reproduction; snake; viviparity; Animals; Female; Lizards; Oviparity; Reproduction; Snakes; Viviparity, Nonmammalian
来源期刊	Nature Ecology & Evolution
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/256824
作者单位	Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom; School of Geographical and Earth Sciences, University of Glasgow, Glasgow, United Kingdom; Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia; School of Biological Sciences, University of Bristol, Bristol, United Kingdom; Inserm U981, Gustave Roussy Cancer Campus, Université Paris Saclay, Villejuif, France
推荐引用方式 GB/T 7714	Recknagel H.,Carruthers M.,Yurchenko A.A.,et al. The functional genetic architecture of egg-laying and live-bearing reproduction in common lizards[J],2021,5(11).
APA	Recknagel H..,Carruthers M..,Yurchenko A.A..,Nokhbatolfoghahai M..,Kamenos N.A..,...&Elmer K.R..(2021).The functional genetic architecture of egg-laying and live-bearing reproduction in common lizards.Nature Ecology & Evolution,5(11).
MLA	Recknagel H.,et al."The functional genetic architecture of egg-laying and live-bearing reproduction in common lizards".Nature Ecology & Evolution 5.11(2021).