气候变化领域集成服务门户(CCPortal): Rational Construction of Fluorescence Turn-Off Fluorinated Carbon Fiber/Ag Composites and Their Anticancer and Antibacterial Activities

CCPortal

DOI	10.1021/acsabm.0c01503
	Rational Construction of Fluorescence Turn-Off Fluorinated Carbon Fiber/Ag Composites and Their Anticancer and Antibacterial Activities
	Wang, Dandan; Peng, Jingyi; Huang, Yan; Sun, Lu; Liu, Mingyue; Li, Hui; Chao, Mianran; Gong, Peiwei; Liu, Zhe; You, Jinmao
通讯作者	Wang, DD ; Gong, PW ; Liu, Z (通讯作者)，Qufu Normal Univ, Sch Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Shandong, Peoples R China. ; Gong, PW (通讯作者)，Northwestern Polytech Univ, State Key Lab Solidificat Proc, Ctr Adv Lubricat & Seal Mat, Xian 710072, Peoples R China.
发表日期	2021
ISSN	2576-6422
起始页码	1749
结束页码	1759
卷号	4 期号:2
英文摘要	Although fluorinated carbon fiber/Ag composites possess unique structure and special charge distribution and exhibit great potential in numerous fields, their synthesis has long been a headache because of inert chemistry bonds, low surface energy, and easy aggregation. Herein, we first demonstrate a fresh concept of constructing the nanoscale hydrosoluble fluorinated carbon fiber oxide (FCO)/Ag composite and then integrate it as a highly effective targeting nanocarrier and photothermal therapy and antibacterial agent. Chemical introduction of oxygen allows us to controllably deposit Ag nanoparticles (AgNPs) for the first time and further facilitates surface modification with folic acid prelinked bovine serum albumin to induce targeted endocytosis toward tumor cells. The structure adjustment of FCO into nanosize and the decoration of AgNPs endow the composite with much better photothermal property than fluorinated carbon materials, and FCO/Ag also serves as an effective fluorescence quencher for doxorubicin, realizing visual monitor of drug adsorption processes by turn-off fluorescence. Meanwhile, both in vitro and in vivo results reveal greatly improved cancer therapeutic effects than single therapy. What is more is that the synergistic interactions of lipophilic fluorine and AgNPs also ensure highly effective antibacterial activity. Our study integrates FCO/Ag as an emerging drug carrier that exhibits excellent targeted efficiency and high photothemal property and reports its unprecedented experimental example in both antibacterial- and anticancer-combined chemo-photothermal therapy.
关键词	TARGETED DRUG-DELIVERY GRAPHENE OXIDE NANOPARTICLES PHOTOLUMINESCENCE AGENTS
英文关键词	carbon material; fluorescence; structure design; drug delivery; antibacteria
语种	英语
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS记录号	WOS:000620346200059
来源期刊	ACS APPLIED BIO MATERIALS
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/255072
作者单位	[Wang, Dandan; Peng, Jingyi; Huang, Yan; Sun, Lu; Liu, Mingyue; Li, Hui; Chao, Mianran; Gong, Peiwei; Liu, Zhe; You, Jinmao] Qufu Normal Univ, Sch Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Shandong, Peoples R China; [You, Jinmao] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810001, Peoples R China; [Gong, Peiwei] Northwestern Polytech Univ, State Key Lab Solidificat Proc, Ctr Adv Lubricat & Seal Mat, Xian 710072, Peoples R China
推荐引用方式 GB/T 7714	Wang, Dandan,Peng, Jingyi,Huang, Yan,et al. Rational Construction of Fluorescence Turn-Off Fluorinated Carbon Fiber/Ag Composites and Their Anticancer and Antibacterial Activities[J]. 中国科学院西北生态环境资源研究院,2021,4(2).
APA	Wang, Dandan.,Peng, Jingyi.,Huang, Yan.,Sun, Lu.,Liu, Mingyue.,...&You, Jinmao.(2021).Rational Construction of Fluorescence Turn-Off Fluorinated Carbon Fiber/Ag Composites and Their Anticancer and Antibacterial Activities.ACS APPLIED BIO MATERIALS,4(2).
MLA	Wang, Dandan,et al."Rational Construction of Fluorescence Turn-Off Fluorinated Carbon Fiber/Ag Composites and Their Anticancer and Antibacterial Activities".ACS APPLIED BIO MATERIALS 4.2(2021).