气候变化领域集成服务门户(CCPortal): Bifenthrin induced toxicity in Ctenopharyngodon idella at an acute concentration: A multi-biomarkers based study

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DOI	10.1016/j.jksus.2021.101752
	Bifenthrin induced toxicity in Ctenopharyngodon idella at an acute concentration: A multi-biomarkers based study
	Ullah, Sana; Ahmad, Shahid; Altaf, Yasir; Dawar, Farman Ullah; Anjum, Syed Ishtiaq; Baig, Mirza Muhammad Faran Ashraf; Fahad, Shah; Al-Misned, F.; Atique, Usman; Guo, Xinle; Nabi, Ghulam; Wanghe, Kunyuan
通讯作者	Ullah, S (通讯作者)，Univ Educ, Dept Zool, Div Sci & Technol, Lahore 54000, Pakistan. ; Nabi, G (通讯作者)，Hebei Normal Univ, Coll Life Sci, Key Lab Anim Physiol Biochem & Mol Biol Hebei Pro, Shijiazhuang 050010, Hebei, Peoples R China. ; Wanghe, KY (通讯作者)，Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Anim Ecol Genom, Key Lab Adaptat & Evolut Plateau Biota, 23rd Xinning Rd, Xining 810008, Qinghai, Peoples R China.
发表日期	2022
ISSN	1018-3647
EISSN	2213-686X
卷号	34 期号:2
英文摘要	Bifenthrin is a (type I; III generation; non-cyano) synthetic pyrethroid used for both agricultural and non-agricultural purposes. Due to its common use, it is widely reported from different parts of the world. Its use is on a continuous rise, which poses a significant risk to non-target organisms including fish. Therefore, the current study was undertaken to assess multiple biomarkers-based toxicological endpoints of bifenthrin-exposed Ctenopharyngodon idella, grass carp. The first part of the research evaluated the LC50 of bifenthrin against grass carp for 96 h, followed by investigating its effect on their biochemical profile [total protein; antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione peroxidase (GSH-Px), glutathione reductase (GR), and glutathione-s-transferase (GST); serum biochemical parameters including chloride, magnesium, sodium, potassium, albumin, total bilirubin, cholesterol, inorganic phosphate, total protein, and urea; DNA damage in term of tail length, % tail DNA, tail moment, and olive tail moment (OTM)], physiological disruption [whole body cortisol, Acetylcholinesterase (AChE), glucose], hematological profile [red blood cells (RBCs), white blood cells (WBCs), hemoglobin (Hb), platelets, packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular haemoglobin concentration (MCHC)], and behav-ioral inconsistencies (hyperactiveness, hypoactiveness, equilibrium loss, rapid swimming, adapting ver-tical position, jumping, etc.). At acute concentration bifenthrin exposure induced stress, evaluated in terms of reactive oxygen species (ROS) and lipid peroxidation (LPO), which led to different subtle changes in the behavioral, biochemical, and hematological profile of grass carp. The current study explicates risks posed by bifenthrin on fish with underlying the possible mechanism of toxicity and supports the necessity to investigate multiple biomarkers-based toxicological endpoints in chemical risk assessment and safety analysis using fish as a model organism. Bifenthrin was classified as a highly toxic pesticide for grass carp. (c) 2021 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
关键词	CIS-BIFENTHRIN PYRETHROID BIFENTHRIN OXIDATIVE STRESS EXPOSURE FISH URBAN IMMUNOTOXICITY TRANSCRIPTION INSECTICIDE GLUTATHIONE
英文关键词	Synthetic pyrethroids; Bifenthrin; Oxidative stress; Behavioral disruption; Biochemical profiling; DNA damage; Hematotoxicity
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000755176600005
来源期刊	JOURNAL OF KING SAUD UNIVERSITY SCIENCE
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254742
作者单位	[Ullah, Sana] Univ Educ, Dept Zool, Div Sci & Technol, Lahore 54000, Pakistan; [Ahmad, Shahid; Nabi, Ghulam] Hebei Normal Univ, Coll Life Sci, Key Lab Anim Physiol Biochem & Mol Biol Hebei Pro, Shijiazhuang 050010, Hebei, Peoples R China; [Altaf, Yasir] Univ Educ, Dept Chem, Div Sci & Technol, Lahore 54000, Pakistan; [Dawar, Farman Ullah; Anjum, Syed Ishtiaq] Kohat Univ Sci & Technol KUST, Dept Zool, Kohat 26000, Khyber Pakhtunk, Pakistan; [Baig, Mirza Muhammad Faran Ashraf] Univ Hong Kong, Lab Biomed Engn Novel Biofunct & Pharmaceut Nanom, Hong Kong 999077, Peoples R China; [Fahad, Shah] Univ Haripur, Dept Agron, Haripur 22620, Khyber Pakhtunk, Pakistan; [Al-Misned, F.] King Saud Univ, Coll Sci, Dept Zool, Riyadh 11451, Saudi Arabia; [Atique, Usman] Chungnam Natl Univ, Coll Biol Syst, Daejeon 34134, South Korea; [Guo, Xinle] Qinghai Normal Univ, Acad Plateau Sci & Sustainabil, Coll Life Sci, Xining, Peoples R China; [Wanghe, Kunyuan] Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Ani...
推荐引用方式 GB/T 7714	Ullah, Sana,Ahmad, Shahid,Altaf, Yasir,et al. Bifenthrin induced toxicity in Ctenopharyngodon idella at an acute concentration: A multi-biomarkers based study[J]. 中国科学院西北生态环境资源研究院,2022,34(2).
APA	Ullah, Sana.,Ahmad, Shahid.,Altaf, Yasir.,Dawar, Farman Ullah.,Anjum, Syed Ishtiaq.,...&Wanghe, Kunyuan.(2022).Bifenthrin induced toxicity in Ctenopharyngodon idella at an acute concentration: A multi-biomarkers based study.JOURNAL OF KING SAUD UNIVERSITY SCIENCE,34(2).
MLA	Ullah, Sana,et al."Bifenthrin induced toxicity in Ctenopharyngodon idella at an acute concentration: A multi-biomarkers based study".JOURNAL OF KING SAUD UNIVERSITY SCIENCE 34.2(2022).