气候变化领域集成服务门户(CCPortal): Antihypertensive Effect of Galegine from Biebersteinia heterostemon in Rats

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DOI	10.3390/molecules26164830
	Antihypertensive Effect of Galegine from Biebersteinia heterostemon in Rats
	Wang, Weien; Zhang, Xiaofeng
通讯作者	Wang, WE (通讯作者)，Qinghai Normal Univ, Sch Chem & Chem Engn, Xining 810008, Peoples R China. ; Wang, WE (通讯作者)，Chinese Acad Sci, Northwest Inst Plateau Biol, Xining 810007, Peoples R China. ; Wang, WE (通讯作者)，Univ Chinese Acad Sci, Sch Chem, Beijing 100049, Peoples R China.
发表日期	2021
EISSN	1420-3049
卷号	26 期号:16
英文摘要	The aerial part of Biebersteinia heterostemon Maxim. (Geraniaceae Biebersteiniaceae) known as ming jian na bao in Chinese, has been traditionally used in Tibetan folk medicine for treatment of diabetes and hypertension. The aim of the present study was to evaluate the effects of galegine obtained from an ethanol extract of the entire Biebersteinia heterostemon plant on the rat's cardiovascular system in order to characterize its contributions as an antihypertensive agent. The antihypertensive effect of galegine was investigated in pentobarbital-anesthetized hypertensive rats at three dose levels based on the LD50 of galegine. Meanwhile a positive control group received dimaprit with the same procedure. Dimaprit infusion induced a significant hypotension which declined by an average margin of 20%. Simultaneously, single administration of galegine at the doses of 2.5, 5, and 10 mg/kg by intraperitoneal injection induced an immediate and dose-dependent decrease in mean arterial blood pressure (MABP) by an average margin of 40% with a rapid increase in heart rate (HR). We demonstrated that galegine is effective in reducing blood pressure in anesthetized hypertensive rats with rapid onset and a dose-related duration of the effects. The results indicate that galegine was the bioactive compound which can be used as a pharmacophore to design new hypertensive agents.
关键词	HISTAMINE CELLS
英文关键词	Biebersteinia heterostemon; galegine; hypotensive; toxicity
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000689868300001
来源期刊	MOLECULES
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254490
作者单位	[Wang, Weien] Qinghai Normal Univ, Sch Chem & Chem Engn, Xining 810008, Peoples R China; [Wang, Weien; Zhang, Xiaofeng] Chinese Acad Sci, Northwest Inst Plateau Biol, Xining 810007, Peoples R China; [Wang, Weien] Univ Chinese Acad Sci, Sch Chem, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Weien,Zhang, Xiaofeng. Antihypertensive Effect of Galegine from Biebersteinia heterostemon in Rats[J]. 中国科学院西北生态环境资源研究院,2021,26(16).
APA	Wang, Weien,&Zhang, Xiaofeng.(2021).Antihypertensive Effect of Galegine from Biebersteinia heterostemon in Rats.MOLECULES,26(16).
MLA	Wang, Weien,et al."Antihypertensive Effect of Galegine from Biebersteinia heterostemon in Rats".MOLECULES 26.16(2021).