气候变化领域集成服务门户(CCPortal): Separation of a new triterpenoid saponin together with six known ones from Clematis tangutica (Maxim.) Korsh and evaluation of their cytotoxic activities

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DOI	10.1080/14786419.2021.1984468
	Separation of a new triterpenoid saponin together with six known ones from Clematis tangutica (Maxim.) Korsh and evaluation of their cytotoxic activities
	Wei, Yangfei; Chen, Tao; Wang, Shuo; Shen, Cheng; Yan, Shuping; Song, Zhibo; Liu, Yarong; Yang, Fengmei; Hai, Ping; Li, Yulin
通讯作者	Li, YL (通讯作者)，Chinese Acad Sci, Northwest Inst Plateau Biol, Xining, Peoples R China. ; Hai, P (通讯作者)，Qinghai Inst Food & Drug Control, Xining, Peoples R China.
发表日期	2020
ISSN	1478-6419
EISSN	1478-6427
英文摘要	A new triterpenoid saponin, 3-O-beta-D-allopyranosyl (1 -> 3)-alpha-L-rhamnopyranosyl (1 -> 2)-alpha-L-arabinopyranosyl hederagenin 28-O-alpha-L-rhamnopyranosyl (1 -> 4)-beta-D-glucopyranosyl (1 -> 6)-beta-D-glucopyranosyl ester (IV), together with six known ones Hederacholichiside F (I), Tanguticoside B (II), Tauroside St-H-1 (III), Hederoside H-1 (V), Kalopanaxsaponin G (VI), Hederasaponin B (VII) were separated from Clematis tangutica (Maxim.) Korsh. Their cytotoxic activities were evaluated. Saponins IV (new compound) and I showed selective inhibitory activities against HGC-27 with IC50 values of 20.17 and 66.18 mu M. Saponin VII exhibited extensive inhibitory action against HGC-27, Hela and SK-OV-3 with IC50 values of 16.47-71.36 mu M. Saponin III showed selective inhibitory activity against SK-OV-3 with the IC50 value of 48.70 mu M. All isolated saponins were inactive (IC50 >150 mu M) to GES-1.
关键词	CONSTITUENTS
英文关键词	Clematis tangutica (Maxim; ) Korsh; triterpenoid saponins; new compound; high-speed counter-current chromatography; cytotoxic activities
语种	英语
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
WOS类目	Chemistry, Applied ; Chemistry, Medicinal
WOS记录号	WOS:000702240500001
来源期刊	NATURAL PRODUCT RESEARCH
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254439
作者单位	[Wei, Yangfei; Chen, Tao; Wang, Shuo; Shen, Cheng; Yan, Shuping; Song, Zhibo; Li, Yulin] Chinese Acad Sci, Northwest Inst Plateau Biol, Xining, Peoples R China; [Wei, Yangfei; Chen, Tao; Shen, Cheng; Yan, Shuping; Song, Zhibo] Univ Chinese Acad Sci, Savaid Med Sch, Beijing, Peoples R China; [Wei, Yangfei] Hexi Univ, Key Lab Hexi Corridor Resources Utilizat Gansu, Zhangye, Peoples R China; [Liu, Yarong; Yang, Fengmei; Hai, Ping] Qinghai Inst Food & Drug Control, Xining, Peoples R China
推荐引用方式 GB/T 7714	Wei, Yangfei,Chen, Tao,Wang, Shuo,et al. Separation of a new triterpenoid saponin together with six known ones from Clematis tangutica (Maxim.) Korsh and evaluation of their cytotoxic activities[J]. 中国科学院西北生态环境资源研究院,2020.
APA	Wei, Yangfei.,Chen, Tao.,Wang, Shuo.,Shen, Cheng.,Yan, Shuping.,...&Li, Yulin.(2020).Separation of a new triterpenoid saponin together with six known ones from Clematis tangutica (Maxim.) Korsh and evaluation of their cytotoxic activities.NATURAL PRODUCT RESEARCH.
MLA	Wei, Yangfei,et al."Separation of a new triterpenoid saponin together with six known ones from Clematis tangutica (Maxim.) Korsh and evaluation of their cytotoxic activities".NATURAL PRODUCT RESEARCH (2020).