气候变化领域集成服务门户(CCPortal): Transcriptome Profiles of the Liver in Two Cold-Exposed Sheep Breeds Revealed Different Mechanisms and Candidate Genes for Thermogenesis

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DOI	10.1155/2021/5510297
	Transcriptome Profiles of the Liver in Two Cold-Exposed Sheep Breeds Revealed Different Mechanisms and Candidate Genes for Thermogenesis
	Jiao, Dan; Ji, Kaixi; Wang, Wenqiang; Liu, Hu; Zhou, Jianwei; Degen, A. Allan; Zhang, Yunsheng; Zhou, Ping; Yang, Guo
通讯作者	Yang, G (通讯作者)，Chinese Acad Sci, Northwest Inst Ecol Environm & Resources, Lanzhou 730000, Peoples R China. ; Yang, G (通讯作者)，Chinese Acad Sci, Northwest Inst Ecol Environm & Resources, Key Lab Stress Physiol & Ecol, Lanzhou 730000, Gansu, Peoples R China.
发表日期	2021
ISSN	0016-6723
EISSN	1469-5073
卷号	2021
英文摘要	Cold-induced thermogenesis plays an important role in the survival of lambs exposed to low air temperatures. The liver produces and mediates heat production in mammals; however, to date, little is known about the role of liver genes in cold-induced thermogenesis in lambs. In this study, the difference in the liver transcriptome between Altay and Hu ewe lambs was compared. Because of different backgrounds of the two breeds, we hypothesized that the transcriptome profiles of the liver would differ between breeds when exposed to cold. Cold-exposed Altay lambs activated 8 candidate genes (ACTA1, MYH1, MYH2, MYL1, MYL2, TNNC1, TNNC2, and TNNT3) involved in muscle shivering thermogenesis; 3 candidate genes (ATP2A1, SLN, and CKM) involved in muscle nonshivering thermogenesis related to the Ca2+ signal and creatine cycle; and 6 candidate genes (PFKM, ALDOC, PGAM2, ENO2, ENO3, and ENO4) involved in enhancing liver metabolism. In contrast, the liver may not act as the main tissue for thermogenesis in cold-exposed Hu lambs. We concluded that Altay lambs rely on liver-mediated shivering and nonshivering thermogenesis by muscle tissue to a greater extent than Hu lambs. Results from this study could provide a theoretical foundation for the breeding and production of cold-resistant lambs.
关键词	BROWN ADIPOSE-TISSUE FATTY-ACID SYNTHESIS HEAT-PRODUCTION NONSHIVERING THERMOGENESIS ENERGY-EXPENDITURE LIPID-METABOLISM SARCOLIPIN INFLAMMATION DEFICIENCY EXPRESSION
语种	英语
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000687446900001
来源期刊	GENETICS RESEARCH
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254411
作者单位	[Jiao, Dan; Ji, Kaixi; Yang, Guo] Chinese Acad Sci, Northwest Inst Ecol Environm & Resources, Lanzhou 730000, Peoples R China; [Jiao, Dan; Ji, Kaixi] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Jiao, Dan; Ji, Kaixi; Yang, Guo] Chinese Acad Sci, Northwest Inst Ecol Environm & Resources, Key Lab Stress Physiol & Ecol, Lanzhou 730000, Gansu, Peoples R China; [Wang, Wenqiang; Liu, Hu; Zhou, Jianwei] Lanzhou Univ, Sch Life Sci, Lanzhou 730020, Peoples R China; [Degen, A. Allan] Ben Gurion Univ Negev, Blaustein Inst Desert Res, Wyler Dept Dryland Agr, Desert Anim Adaptat & Husb, IL-8410500 Beer Sheva, Israel; [Zhang, Yunsheng] Xinjiang Acad Anim Sci, Inst Anim Husb, Urumqi 830000, Xinjiang, Peoples R China; [Zhou, Ping] Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi 832000, Peoples R China
推荐引用方式 GB/T 7714	Jiao, Dan,Ji, Kaixi,Wang, Wenqiang,et al. Transcriptome Profiles of the Liver in Two Cold-Exposed Sheep Breeds Revealed Different Mechanisms and Candidate Genes for Thermogenesis[J]. 中国科学院西北生态环境资源研究院,2021,2021.
APA	Jiao, Dan.,Ji, Kaixi.,Wang, Wenqiang.,Liu, Hu.,Zhou, Jianwei.,...&Yang, Guo.(2021).Transcriptome Profiles of the Liver in Two Cold-Exposed Sheep Breeds Revealed Different Mechanisms and Candidate Genes for Thermogenesis.GENETICS RESEARCH,2021.
MLA	Jiao, Dan,et al."Transcriptome Profiles of the Liver in Two Cold-Exposed Sheep Breeds Revealed Different Mechanisms and Candidate Genes for Thermogenesis".GENETICS RESEARCH 2021(2021).