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DOI	10.1016/j.ijbiomac.2021.08.185
	Structure and immunomodulatory activity of a water-soluble alpha-glucan from Hirsutella sinensis mycelia
	Rong, Lin; Li, Guoqiang; Zhang, Yuxia; Xiao, Yuancan; Qiao, Yajun; Yang, Mengmeng; Wei, Lixin; Bi, Hongtao; Gao, Tingting
通讯作者	Bi, HT (通讯作者)，Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Pharmacol & Safe, Xining 810008, Peoples R China. ; Gao, TT (通讯作者)，Southern Med Univ, Peoples Hosp Jiangmen, Dept Psychiat, 19 Penglai Rd, Jiangmen 529000, Peoples R China.
发表日期	2021
ISSN	0141-8130
EISSN	1879-0003
起始页码	857
结束页码	868
卷号	189
英文摘要	Hirsutella sinensis, the anamorph of Ophiocordyceps sinensis (syn. Cordyceps sinensis), is a great substitute for precious and rare wild Cordyceps sinensis to effectively treat a variety of lung and kidney diseases. In this study, an alpha-glucan (named as HSWP-2a) was obtained by hot water extraction, DEAE-cellulose separation, and Sepharose CL-6B purification from H. sinensis mycelia. Different from known alpha-glucans, HSWP-2a is an alpha-(1 -> 4)-D-glucan that branched at O-6, O-3, or O-2 with a terminal 1-linked alpha-D-Glcp as side chain, with an average molecular weight of 870.70 kDa. Immunological tests showed that HSWP-2a could remarkably enhance the phagocytosis of macrophages and increase the production of NO, IL-113, IL-6, and TNF-alpha, via activating the p38, JNK, and NF-KB signaling pathways. Moreover, HSWP-2a could significantly promote splenic lymphocyte proliferation. Taken together, HSWP-2a may be potentially utilized as a natural immunomodulatory agent.
关键词	PATTERN-RECOGNITION RECEPTORS NF-KAPPA-B IMMUNOSTIMULATORY ACTIVITY ANTIOXIDANT ACTIVITY CORDYCEPS-SINENSIS POLYSACCHARIDE ACTIVATION ANAMORPH PHAGOCYTOSIS ELUCIDATION
英文关键词	Hirsutella sinensis; alpha-Glucan; Structure; Immunomodulatory activity
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS记录号	WOS:000702867500009
来源期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254142
作者单位	[Rong, Lin; Li, Guoqiang; Zhang, Yuxia; Xiao, Yuancan; Qiao, Yajun; Wei, Lixin; Bi, Hongtao] Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Pharmacol & Safe, Xining 810008, Peoples R China; [Gao, Tingting] Southern Med Univ, Peoples Hosp Jiangmen, Dept Psychiat, 19 Penglai Rd, Jiangmen 529000, Peoples R China; [Yang, Mengmeng] Qinghai Univ, Med Coll, Xining 810001, Peoples R China; [Li, Guoqiang; Xiao, Yuancan; Wei, Lixin] Northwest Inst Plateau Biol, CAS Key Lab Tibetan Med Res, Xining 810001, Peoples R China; [Rong, Lin; Zhang, Yuxia; Qiao, Yajun; Bi, Hongtao] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Rong, Lin; Gao, Tingting] Southern Med Univ, Sch Publ Hlth, Dept Psychol, Guangzhou 510515, Peoples R China
推荐引用方式 GB/T 7714	Rong, Lin,Li, Guoqiang,Zhang, Yuxia,et al. Structure and immunomodulatory activity of a water-soluble alpha-glucan from Hirsutella sinensis mycelia[J]. 中国科学院西北生态环境资源研究院,2021,189.
APA	Rong, Lin.,Li, Guoqiang.,Zhang, Yuxia.,Xiao, Yuancan.,Qiao, Yajun.,...&Gao, Tingting.(2021).Structure and immunomodulatory activity of a water-soluble alpha-glucan from Hirsutella sinensis mycelia.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,189.
MLA	Rong, Lin,et al."Structure and immunomodulatory activity of a water-soluble alpha-glucan from Hirsutella sinensis mycelia".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 189(2021).