气候变化领域集成服务门户(CCPortal): The plant secondary compound swainsonine reshapes gut microbiota in plateau pikas (Ochotona curzoniae)

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DOI	10.1007/s00253-021-11478-6
	The plant secondary compound swainsonine reshapes gut microbiota in plateau pikas (Ochotona curzoniae)
	Ren, Shien; Fan, Chao; Zhang, Liangzhi; Tang, Xianjiang; Fu, Haibo; Liu, Chuanfa; Jia, Shangang; Zhang, Yanming
通讯作者	Zhang, YM (通讯作者)，Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810008, Peoples R China. ; Zhang, YM (通讯作者)，Qinghai Prov Key Lab Anim Ecol Genom, Xining 810008, Peoples R China. ; Jia, SG (通讯作者)，China Agr Univ, Coll Grassland Sci & Technol, Beijing 100193, Peoples R China.
发表日期	2021
ISSN	0175-7598
EISSN	1432-0614
起始页码	6419
结束页码	6433
卷号	105 期号:16-17
英文摘要	Plants produce various plant secondary compounds (PSCs) to deter the foraging of herbivorous mammals. However, little is known about whether PSCs can reshape gut microbiota and promote gut homeostasis of hosts. Using 16S rDNA sequencing to investigate the effects of PSCs on the gut microbiota of small herbivorous mammals, we studied plateau pikas (Ochotona curzoniae) fed diets containing swainsonine (SW) extracted from Oxytropis ochrocephala. Our results showed that both long- and short-term treatment of a single artificial diet in the laboratory significantly reduced alpha diversity and significantly affected beta diversity, core bacteria abundance, and bacterial functions in pikas. After SW was added to the artificial diet, the alpha diversity significantly increased in the long-term treatment, and core bacteria (e.g., Akkermansiaceae) with altered relative abundances in the two treatments showed no significant difference compared with pikas in the wild. The complexity of the co-occurrence network structure was reduced in the artificial diet, but it increased after SW was added in both treatments. Further, the abundances of bacteria related to altered alanine, aspartate, and glutamate metabolism in the artificial diet were restored in response to SW. SW further decreased the concentration of short-chain fatty acids (SCFAs) in both treatments. Our results suggest that PSCs play a key role in regulating gut microbiota community and intestinal homeostasis, thereby maintaining host health.
关键词	INTESTINAL MICROBIOTA TRANS-RESVERATROL DIET DIVERSITY WILD CAPTIVITY LIVESTOCK DISEASE TALK
英文关键词	Gut microbiota; 16S rDNA; Plant secondary compounds; Swainsonine; Plateau pika (Ochotona curzoniae)
语种	英语
WOS研究方向	Biotechnology & Applied Microbiology
WOS类目	Biotechnology & Applied Microbiology
WOS记录号	WOS:000685763900004
来源期刊	APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/254141
作者单位	[Ren, Shien; Fan, Chao; Zhang, Liangzhi; Tang, Xianjiang; Fu, Haibo; Liu, Chuanfa; Zhang, Yanming] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810008, Peoples R China; [Ren, Shien; Fan, Chao; Tang, Xianjiang; Fu, Haibo; Liu, Chuanfa; Zhang, Yanming] Qinghai Prov Key Lab Anim Ecol Genom, Xining 810008, Peoples R China; [Ren, Shien; Fan, Chao; Tang, Xianjiang; Fu, Haibo] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Zhang, Liangzhi] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Restorat Ecol Cold Area Qinghai Prov, Xining 810008, Peoples R China; [Jia, Shangang] China Agr Univ, Coll Grassland Sci & Technol, Beijing 100193, Peoples R China
推荐引用方式 GB/T 7714	Ren, Shien,Fan, Chao,Zhang, Liangzhi,et al. The plant secondary compound swainsonine reshapes gut microbiota in plateau pikas (Ochotona curzoniae)[J]. 中国科学院西北生态环境资源研究院,2021,105(16-17).
APA	Ren, Shien.,Fan, Chao.,Zhang, Liangzhi.,Tang, Xianjiang.,Fu, Haibo.,...&Zhang, Yanming.(2021).The plant secondary compound swainsonine reshapes gut microbiota in plateau pikas (Ochotona curzoniae).APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,105(16-17).
MLA	Ren, Shien,et al."The plant secondary compound swainsonine reshapes gut microbiota in plateau pikas (Ochotona curzoniae)".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 105.16-17(2021).