气候变化领域集成服务门户(CCPortal): Multiple mechanisms drive genomic adaptation to extreme O2 levels in Drosophila melanogaster

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DOI	10.1038/s41467-021-21281-6
	Multiple mechanisms drive genomic adaptation to extreme O2 levels in Drosophila melanogaster
	Iranmehr A.; Stobdan T.; Zhou D.; Zhao H.; Kryazhimskiy S.; Bafna V.; Haddad G.G.
发表日期	2021
卷号	12 期号:1
英文摘要	To detect the genomic mechanisms underlying evolutionary dynamics of adaptation in sexually reproducing organisms, we analyze multigenerational whole genome sequences of Drosophila melanogaster adapting to extreme O2 conditions over an experiment conducted for nearly two decades. We develop methods to analyze time-series genomics data and predict adaptive mechanisms. Here, we report a remarkable level of synchronicity in both hard and soft selective sweeps in replicate populations as well as the arrival of favorable de novo mutations that constitute a few asynchronized sweeps. We additionally make direct experimental observations of rare recombination events that combine multiple alleles on to a single, better-adapted haplotype. Based on the analyses of the genes in genomic intervals, we provide a deeper insight into the mechanisms of genome adaptation that allow complex organisms to survive harsh environments. © 2021, The Author(s).
语种	英语
scopus关键词	Notch receptor; oxygen; phosphatidylinositol 3 kinase; protein IRE1; Rho guanine nucleotide binding protein; vasculotropin; oxygen; adaptation; environmental conditions; fly; genomics; oxygen; recombination; adaptation; Article; controlled study; DNA degradation; Drosophila melanogaster; environmental change; female; gene frequency; gene location; gene mutation; gene replication; genetic drift; genetic recombination; genetic variability; haplotype; human; insect genome; Markov chain; nonhuman; Notch signaling; RNA interference; selective sweep; single nucleotide polymorphism; time series analysis; VEGF signaling; whole genome sequencing; adaptation; allele; animal; Drosophila melanogaster; genetics; genomics; male; metabolism; molecular evolution; Drosophila melanogaster; Adaptation, Physiological; Alleles; Animals; Drosophila melanogaster; Evolution, Molecular; Female; Gene Frequency; Genome, Insect; Genomics; Haplotypes; Male; Oxygen; Whole Genome Sequencing
来源期刊	Nature Communications
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251557
作者单位	Department of Electrical & Computer Engineering, University of California, San Diego, La Jolla, CA, United States; Division of Respiratory Medicine, Department of Pediatrics, University of California, San Diego, La Jolla, CA, United States; Division of Biological Sciences, University of California, San Diego, La Jolla, CA, United States; Department of Computer Science & Engineering, University of California, San Diego, La Jolla, CA, United States; Department of Neurosciences, University of California, San Diego, La Jolla, CA, United States; Rady Children’s Hospital, San Diego, CA, United States
推荐引用方式 GB/T 7714	Iranmehr A.,Stobdan T.,Zhou D.,et al. Multiple mechanisms drive genomic adaptation to extreme O2 levels in Drosophila melanogaster[J],2021,12(1).
APA	Iranmehr A..,Stobdan T..,Zhou D..,Zhao H..,Kryazhimskiy S..,...&Haddad G.G..(2021).Multiple mechanisms drive genomic adaptation to extreme O2 levels in Drosophila melanogaster.Nature Communications,12(1).
MLA	Iranmehr A.,et al."Multiple mechanisms drive genomic adaptation to extreme O2 levels in Drosophila melanogaster".Nature Communications 12.1(2021).