气候变化领域集成服务门户(CCPortal): Direct allele introgression into pure chicken breeds using Sire Dam Surrogate (SDS) mating

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DOI	10.1038/s41467-020-20812-x
	Direct allele introgression into pure chicken breeds using Sire Dam Surrogate (SDS) mating
	Ballantyne M.; Woodcock M.; Doddamani D.; Hu T.; Taylor L.; Hawken R.J.; McGrew M.J.
发表日期	2021
ISSN	2041-1723
卷号	12 期号:1
英文摘要	Poultry is the most abundant livestock species with over 60 billion chickens raised globally per year. The majority of chicken are produced from commercial flocks, however many indigenous chicken breeds play an important role in rural economies as they are well adapted to local environmental and scavenging conditions. The ability to make precise genetic changes in chicken will permit the validation of genetic variants responsible for climate adaptation and disease resilience, and the transfer of beneficial alleles between breeds. Here, we generate a novel inducibly sterile surrogate host chicken. Introducing donor genome edited primordial germ cells into the sterile male and female host embryos produces adult chicken carrying only exogenous germ cells. Subsequent direct mating of the surrogate hosts, Sire Dam Surrogate (SDS) mating, recreates the donor chicken breed carrying the edited allele in a single generation. We demonstrate the introgression and validation of two feather trait alleles, Dominant white and Frizzle into two pure chicken breeds using the SDS surrogate hosts. © 2021, The Author(s).
语种	英语
scopus关键词	caspase 9; adaptive management; allele; embryo; feather; genetic variation; genome; introgression; model validation; poultry; rural economy; sterility; adult; allele; animal cell; Article; chicken breed; controlled study; dam (animal); embryo; feather; female; gene editing; gene locus; gene mutation; homozygote; introgression; Leghorn chicken; male; mating; nonhuman; primordial germ cell; progeny; sire; allele; animal; breeding; chicken; genetics; germ cell; infertility; metabolism; phenotype; procedures; reproducibility; reproduction; Gallus gallus; Trachinotus falcatus; Alleles; Animals; Breeding; Chickens; Feathers; Female; Germ Cells; Infertility; Male; Phenotype; Reproducibility of Results; Reproduction
来源期刊	Nature Communications
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251526
作者单位	Centre for Tropical Livestock Genetics and Health (CTLGH), Edinburgh, United Kingdom; The Roslin Institute and Royal (Dick) School of Veterinary Studies University of Edinburgh, Easter Bush Campus, Midlothian, United Kingdom; Cobb-Europe, Old Ipswich Road, Colchester, United Kingdom
推荐引用方式 GB/T 7714	Ballantyne M.,Woodcock M.,Doddamani D.,et al. Direct allele introgression into pure chicken breeds using Sire Dam Surrogate (SDS) mating[J],2021,12(1).
APA	Ballantyne M..,Woodcock M..,Doddamani D..,Hu T..,Taylor L..,...&McGrew M.J..(2021).Direct allele introgression into pure chicken breeds using Sire Dam Surrogate (SDS) mating.Nature Communications,12(1).
MLA	Ballantyne M.,et al."Direct allele introgression into pure chicken breeds using Sire Dam Surrogate (SDS) mating".Nature Communications 12.1(2021).