气候变化领域集成服务门户(CCPortal): Diet and gut microbiome enterotype are associated at the population level in African buffalo

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DOI	10.1038/s41467-021-22510-8
	Diet and gut microbiome enterotype are associated at the population level in African buffalo
	Couch C.E.; Stagaman K.; Spaan R.S.; Combrink H.J.; Sharpton T.J.; Beechler B.R.; Jolles A.E.
发表日期	2021
ISSN	2041-1723
卷号	12 期号:1
英文摘要	Studies in humans and laboratory animals link stable gut microbiome “enterotypes” with long-term diet and host health. Understanding how this paradigm manifests in wild herbivores could provide a mechanistic explanation of the relationships between microbiome dynamics, changes in dietary resources, and outcomes for host health. We identify two putative enterotypes in the African buffalo gut microbiome. The enterotype prevalent under resource-abundant dietary regimes, regardless of environmental conditions, has high richness, low between- and within-host beta diversity, and enrichment of genus Ruminococcaceae-UCG-005. The second enterotype, prevalent under restricted dietary conditions, has reduced richness, elevated beta diversity, and enrichment of genus Solibacillus. Population-level gamma diversity is maintained during resource restriction by increased beta diversity between individuals, suggesting a mechanism for population-level microbiome resilience. We identify three pathogens associated with microbiome variation depending on host diet, indicating that nutritional background may impact microbiome-pathogen dynamics. Overall, this study reveals diet-driven enterotype plasticity, illustrates ecological processes that maintain microbiome diversity, and identifies potential associations between diet, enterotype, and disease. © 2021, The Author(s).
语种	英语
scopus关键词	genomic DNA; host factor; bacterial DNA; RNA 16S; cattle; digestion and nutrition; digestive system; geodiversity; microorganism; species diversity; species richness; African buffalo; animal experiment; animal model; Article; Bacillus; Bacteroides; Bovine respiratory syncytial virus; bovine tuberculosis; bovine viral diarrhea; Bovine viral diarrhea virus 1; Christensenellaceae; controlled study; diet supplementation; dietary intake; disease association; ecosystem resilience; environmental factor; gastrointestinal tract; human; immune system; infectious agent; intestine flora; Lysinibacillus; microbial diversity; Mycobacterium bovis; nonhuman; plasticity; polymerase chain reaction; population; prevalence; respiratory tract infection; Rikenellaceae; Romboutsia; Ruminococcaceae; sandwich ELISA; Solibacillus; species richness; within host interaction; animal; buffalo; communicable disease; feces; feeding behavior; Firmicutes; genetics; immunology; incidence; intestine flora; isolation and purification; metagenomics; microbiology; phylogeny; physiology; Planococcaceae; South Africa; symbiosis; veterinary medicine; Syncerus caffer; Animals; Buffaloes; Communicable Diseases; DNA, Bacterial; Feces; Feeding Behavior; Firmicutes; Gastrointestinal Microbiome; Incidence; Metagenomics; Phylogeny; Planococcaceae; Prevalence; RNA, Ribosomal, 16S; South Africa; Symbiosis
来源期刊	Nature Communications
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251470
作者单位	Department of Integrative Biology, Oregon State University, Corvallis, OR, United States; Department of Microbiology, Oregon State University, Corvallis, OR, United States; Department of Fisheries & Wildlife, Oregon State University, Corvallis, OR, United States; Department of Statistics, Oregon State University, Corvallis, OR, United States; Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States
推荐引用方式 GB/T 7714	Couch C.E.,Stagaman K.,Spaan R.S.,et al. Diet and gut microbiome enterotype are associated at the population level in African buffalo[J],2021,12(1).
APA	Couch C.E..,Stagaman K..,Spaan R.S..,Combrink H.J..,Sharpton T.J..,...&Jolles A.E..(2021).Diet and gut microbiome enterotype are associated at the population level in African buffalo.Nature Communications,12(1).
MLA	Couch C.E.,et al."Diet and gut microbiome enterotype are associated at the population level in African buffalo".Nature Communications 12.1(2021).