气候变化领域集成服务门户(CCPortal): Non-additive microbial community responses to environmental complexity

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DOI	10.1038/s41467-021-22426-3
	Non-additive microbial community responses to environmental complexity
	Pacheco A.R.; Osborne M.L.; Segrè D.
发表日期	2021
ISSN	2041-1723
卷号	12 期号:1
英文摘要	Environmental composition is a major, though poorly understood, determinant of microbiome dynamics. Here we ask whether general principles govern how microbial community growth yield and diversity scale with an increasing number of environmental molecules. By assembling hundreds of synthetic consortia in vitro, we find that growth yield can remain constant or increase in a non-additive manner with environmental complexity. Conversely, taxonomic diversity is often much lower than expected. To better understand these deviations, we formulate metrics for epistatic interactions between environments and use them to compare our results to communities simulated with experimentally-parametrized consumer resource models. We find that key metabolic and ecological factors, including species similarity, degree of specialization, and metabolic interactions, modulate the observed non-additivity and govern the response of communities to combinations of resource pools. Our results demonstrate that environmental complexity alone is not sufficient for maintaining community diversity, and provide practical guidance for designing and controlling microbial ecosystems. © 2021, The Author(s).
语种	英语
scopus关键词	community response; complexity; experimental study; growth; microbial community; article; consumer; human; in vitro study; microbial community; simulation; specialization; bacterium; biodiversity; bioengineering; biological model; cell culture technique; culture medium; genetics; metabolism; metabolomics; microbial consortium; physiology; procedures; carbon; Bacteria; Biodiversity; Bioengineering; Carbon; Cell Culture Techniques; Culture Media; Metabolomics; Microbial Consortia; Models, Biological; Nutrients
来源期刊	Nature Communications
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251468
作者单位	Graduate Program in Bioinformatics, Boston University, Boston, MA, United States; Biological Design Center, Boston University, Boston, MA, United States; Department of Biology, Boston University, Boston, MA, United States; Department of Biomedical Engineering, Boston University, Boston, MA, United States; Department of Physics, Boston University, Boston, MA, United States
推荐引用方式 GB/T 7714	Pacheco A.R.,Osborne M.L.,Segrè D.. Non-additive microbial community responses to environmental complexity[J],2021,12(1).
APA	Pacheco A.R.,Osborne M.L.,&Segrè D..(2021).Non-additive microbial community responses to environmental complexity.Nature Communications,12(1).
MLA	Pacheco A.R.,et al."Non-additive microbial community responses to environmental complexity".Nature Communications 12.1(2021).