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DOI	10.1038/s41467-021-23558-2
	Cis-regulatory evolution spotlights species differences in the adaptive potential of gene expression plasticity
	He F.; Steige K.A.; Kovacova V.; Göbel U.; Bouzid M.; Keightley P.D.; Beyer A.; de Meaux J.
发表日期	2021
ISSN	2041-1723
卷号	12 期号:1
英文摘要	Phenotypic plasticity is the variation in phenotype that a single genotype can produce in different environments and, as such, is an important component of individual fitness. However, whether the effect of new mutations, and hence evolution, depends on the direction of plasticity remains controversial. Here, we identify the cis-acting modifications that have reshaped gene expression in response to dehydration stress in three Arabidopsis species. Our study shows that the direction of effects of most cis-regulatory variants differentiating the response between A. thaliana and the sister species A. lyrata and A. halleri depends on the direction of pre-existing plasticity in gene expression. A comparison of the rate of cis-acting variant accumulation in each lineage indicates that the selective forces driving adaptive evolution in gene expression favors regulatory changes that magnify the stress response in A. lyrata. The evolutionary constraints measured on the amino-acid sequence of these genes support this interpretation. In contrast, regulatory changes that mitigate the plastic response to stress evolved more frequently in A. halleri. Our results demonstrate that pre-existing plasticity may be a stepping stone for adaptation, but its selective remodeling differs between lineages. © 2021, The Author(s).
语种	英语
scopus关键词	cis acting element; transcriptome; adaptation; angiosperm; fitness; gene expression; phenotypic plasticity; amino acid sequence; Arabidopsis; Arabidopsis halleri; Arabidopsis lyrata; Article; controlled study; gene expression; gene mutation; nonhuman; plant stress; plasticity; species difference; adaptation; Arabidopsis; drought; gene expression regulation; genetics; molecular evolution; plant breeding; plant gene; regulatory sequence; Arabidopsis; Arabidopsis thaliana; Adaptation, Physiological; Arabidopsis; Droughts; Evolution, Molecular; Gene Expression Regulation, Plant; Genes, Plant; Plant Breeding; Regulatory Elements, Transcriptional; Species Specificity
来源期刊	Nature Communications
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251423
作者单位	CEPLAS, University of Cologne, Cologne, Germany; CECAD, University of Cologne, Cologne, Germany; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom
推荐引用方式 GB/T 7714	He F.,Steige K.A.,Kovacova V.,et al. Cis-regulatory evolution spotlights species differences in the adaptive potential of gene expression plasticity[J],2021,12(1).
APA	He F..,Steige K.A..,Kovacova V..,Göbel U..,Bouzid M..,...&de Meaux J..(2021).Cis-regulatory evolution spotlights species differences in the adaptive potential of gene expression plasticity.Nature Communications,12(1).
MLA	He F.,et al."Cis-regulatory evolution spotlights species differences in the adaptive potential of gene expression plasticity".Nature Communications 12.1(2021).