气候变化领域集成服务门户(CCPortal): Refining models of archaic admixture in Eurasia with ArchaicSeeker 2.0

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DOI	10.1038/s41467-021-26503-5
	Refining models of archaic admixture in Eurasia with ArchaicSeeker 2.0
	Yuan K.; Ni X.; Liu C.; Pan Y.; Deng L.; Zhang R.; Gao Y.; Ge X.; Liu J.; Ma X.; Lou H.; Wu T.; Xu S.
发表日期	2021
ISSN	2041-1723
卷号	12 期号:1
英文摘要	We developed a method, ArchaicSeeker 2.0, to identify introgressed hominin sequences and model multiple-wave admixture. The new method enabled us to discern two waves of introgression from both Denisovan-like and Neanderthal-like hominins in present-day Eurasian populations and an ancient Siberian individual. We estimated that an early Denisovan-like introgression occurred in Eurasia around 118.8–94.0 thousand years ago (kya). In contrast, we detected only one single episode of Denisovan-like admixture in indigenous peoples eastern to the Wallace-Line. Modeling ancient admixtures suggested an early dispersal of modern humans throughout Asia before the Toba volcanic super-eruption 74 kya, predating the initial peopling of Asia as proposed by the traditional Out-of-Africa model. Survived archaic sequences are involved in various phenotypes including immune and body mass (e.g., ZNF169), cardiovascular and lung function (e.g., HHAT), UV response and carbohydrate metabolism (e.g., HYAL1/HYAL2/HYAL3), while “archaic deserts” are enriched with genes associated with skin development and keratinization. © 2021, The Author(s).
语种	英语
scopus关键词	body mass; hominid; introgression; metabolism; numerical model; Africa; Asia; Eurasia; BNC2 protein, human; DNA binding protein; algorithm; animal; Asia; biological model; Europe; genetics; hominid; Homo neanderthalensis; human; human genome; metagenomics; procedures; quantitative trait locus; Russian Federation; single nucleotide polymorphism; Algorithms; Animals; Asia; DNA-Binding Proteins; Europe; Genetic Introgression; Genome, Human; Hominidae; Humans; Metagenomics; Models, Genetic; Neanderthals; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Siberia
来源期刊	Nature Communications
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251321
作者单位	Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China; Department of Mathematics, School of Science, Beijing Jiaotong University, Beijing, 100044, China; State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Center for Evolutionary Biology, School of Life Sciences, Fudan University, Shanghai, 200433, China; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China; School of Computing Sciences, University of East Anglia, Norwich, NR4 7TJ, United Kingdom; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China; Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450052, China; Human Phenome Institute, Fudan University, Shanghai, 201203, China
推荐引用方式 GB/T 7714	Yuan K.,Ni X.,Liu C.,et al. Refining models of archaic admixture in Eurasia with ArchaicSeeker 2.0[J],2021,12(1).
APA	Yuan K..,Ni X..,Liu C..,Pan Y..,Deng L..,...&Xu S..(2021).Refining models of archaic admixture in Eurasia with ArchaicSeeker 2.0.Nature Communications,12(1).
MLA	Yuan K.,et al."Refining models of archaic admixture in Eurasia with ArchaicSeeker 2.0".Nature Communications 12.1(2021).