气候变化领域集成服务门户(CCPortal): Divergent low-density lipoprotein receptor (LDLR) linked to low VSV G-dependent viral infectivity and unique serum lipid profile in zebra finches

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DOI	10.1073/pnas.2025167118
	Divergent low-density lipoprotein receptor (LDLR) linked to low VSV G-dependent viral infectivity and unique serum lipid profile in zebra finches
	Velho T.A.F.; Lovell P.V.; Friedrich S.R.; Olson C.R.; Miles J.; Mueller P.A.; Tavori H.; Fazio S.; Lois C.; Mello C.V.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:18
英文摘要	The low-density lipoprotein receptor (LDLR) is key to cellular cholesterol uptake and is also the main receptor for the vesicular stomatitis virus glycoprotein (VSV G). Here we show that in songbirds LDLR is highly divergent and lacks domains critical for ligand binding and cellular trafficking, inconsistent with universal structure conservation and function across vertebrates. Linked to the LDLR functional domain loss, zebra finches show inefficient infectivity by lentiviruses (LVs) pseudotyped with VSV G, which can be rescued by the expression of human LDLR. Finches also show an atypical plasma lipid distribution that relies largely on high-density lipoprotein (HDL). These findings provide insights into the genetics and evolution of viral infectivity and cholesterol transport mechanisms in vertebrates. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Cholesterol; LDLR; Lentivirus; Viral transduction; VSG G
语种	英语
scopus关键词	cholesterol; high density lipoprotein; lipid; low density lipoprotein receptor; virus glycoprotein; cholesterol; G protein, vesicular stomatitis virus; ligand; lipid; low density lipoprotein receptor; membrane protein; virus envelope protein; adult; animal cell; animal experiment; Article; cell migration; cholesterol transport; controlled study; embryo; evolution; Lentivirus; lipid blood level; lipid fingerprinting; male; nonhuman; priority journal; protein domain; protein expression; pseudotyping; Taeniopygia guttata; Vesiculovirus; viral gene delivery system; viral genetics; virus infectivity; animal; blood; finch; gene expression regulation; genetics; human; metabolism; transport at the cellular level; Animals; Biological Transport; Cholesterol; Finches; Gene Expression Regulation; Humans; Ligands; Lipids; Membrane Glycoproteins; Receptors, LDL; Viral Envelope Proteins
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251194
作者单位	Brain Institute, Federal University of Rio Grande do Norte, Natal, RN 59078970, Brazil; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, United States; Department of Behavioral Neuroscience, Oregon Health & Science University (OHSU), Portland, OR 97239, United States; Knight Cardiovascular Institute, OHSU, Portland, OR 97239, United States; Department of Physiology, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, United States; Department of Immunology, UT Southwestern Medical Center, Dallas, TX 75390, United States
推荐引用方式 GB/T 7714	Velho T.A.F.,Lovell P.V.,Friedrich S.R.,et al. Divergent low-density lipoprotein receptor (LDLR) linked to low VSV G-dependent viral infectivity and unique serum lipid profile in zebra finches[J],2021,118(18).
APA	Velho T.A.F..,Lovell P.V..,Friedrich S.R..,Olson C.R..,Miles J..,...&Mello C.V..(2021).Divergent low-density lipoprotein receptor (LDLR) linked to low VSV G-dependent viral infectivity and unique serum lipid profile in zebra finches.Proceedings of the National Academy of Sciences of the United States of America,118(18).
MLA	Velho T.A.F.,et al."Divergent low-density lipoprotein receptor (LDLR) linked to low VSV G-dependent viral infectivity and unique serum lipid profile in zebra finches".Proceedings of the National Academy of Sciences of the United States of America 118.18(2021).