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DOI	10.1073/pnas.2022516118
	The circadian clock ensures successful DNA replication in cyanobacteria
	Liao Y.; Rust M.J.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:20
英文摘要	Disruption of circadian rhythms causes decreased health and fitness, and evidence from multiple organisms links clock disruption to dysregulation of the cell cycle. However, the function of circadian regulation for the essential process of DNA replication remains elusive. Here, we demonstrate that in the cyanobacterium Synechococcus elongatus, a model organismwith the simplest known circadian oscillator, the clock generates rhythms in DNA replication to minimize the number of open replication forks near dusk that would have to complete after sunset. Metabolic rhythms generated by the clock ensure that resources are available early at night to support any remaining replication forks. Combining mathematical modeling and experiments, we show that metabolic defects caused by clock-environment misalignment result in premature replisome disassembly and replicative abortion in the dark, leaving cells with incomplete chromosomes that persist through the night. Our study thus demonstrates that a major function of this ancient clock in cyanobacteria is to ensure successful completion of genome replication in a cycling environment. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Cell cycle; Circadian clock; Cyanobacteria; DNA replication; Mathematical modeling
语种	英语
scopus关键词	Article; bacterial chromosome; bacterial genome; bacterial metabolism; circadian rhythm; cyanobacterium; DNA replication; nonhuman; priority journal; replisome; Synechococcus elongatus; cell cycle; circadian rhythm; computer simulation; gene expression regulation; genetics; growth, development and aging; metabolism; photoperiodicity; statistical model; Synechococcus; bacterial protein; Bacterial Proteins; Cell Cycle; Circadian Clocks; Circadian Rhythm; Computer Simulation; DNA Replication; Gene Expression Regulation, Bacterial; Models, Statistical; Photoperiod; Synechococcus
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251182
作者单位	Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, United States; Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, United States; Department of Physics, University of Chicago, Chicago, IL 60637, United States
推荐引用方式 GB/T 7714	Liao Y.,Rust M.J.. The circadian clock ensures successful DNA replication in cyanobacteria[J],2021,118(20).
APA	Liao Y.,&Rust M.J..(2021).The circadian clock ensures successful DNA replication in cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America,118(20).
MLA	Liao Y.,et al."The circadian clock ensures successful DNA replication in cyanobacteria".Proceedings of the National Academy of Sciences of the United States of America 118.20(2021).