气候变化领域集成服务门户(CCPortal): Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis

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DOI	10.1073/pnas.2026271118
	Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis
	Ducimetière L.; Lucchiari G.; Litscher G.; Nater M.; Heeb L.; Nuñez N.G.; Wyss L.; Burri D.; Vermeer M.; Gschwend J.; Moor A.E.; Becher B.; van den Broek M.; Tugues S.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:27
英文摘要	The liver is a major metastatic target organ, and little is known about the role of immunity in controlling hepatic metastases. Here, we discovered that the concerted and nonredundant action of two innate lymphocyte subpopulations, conventional natural killer cells (cNKs) and tissue-resident type I innate lymphoid cells (trILC1s), is essential for antimetastatic defense. Using different preclinical models for liver metastasis, we found that trILC1 controls metastatic seeding, whereas cNKs restrain outgrowth. Whereas the killing capacity of trILC1s was not affected by the metastatic microenvironment, the phenotype and function of cNK cells were affected in a cancer type–specific fashion. Thus, individual cancer cell lines orchestrate the emergence of unique cNK subsets, which respond differently to tumor-derived factors. Our findings will contribute to the development of therapies for liver metastasis involving hepatic innate cells. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Conventional NK cells; Innate lymphocytes; Metastatic surveillance; Tissue-resident ILC1s
语种	英语
scopus关键词	alpha1 integrin; interleukin 15; transcriptome; transforming growth factor beta; animal; C57BL mouse; female; gene expression regulation; genetics; immunology; innate immunity; liver; liver tumor; lymphocyte; metabolism; mouse; natural killer cell; pathology; single cell analysis; tumor microenvironment; Animals; Female; Gene Expression Regulation, Neoplastic; Immunity, Innate; Integrin alpha1; Interleukin-15; Killer Cells, Natural; Liver; Liver Neoplasms; Lymphocytes; Mice; Mice, Inbred C57BL; RNA-Seq; Single-Cell Analysis; Transcriptome; Transforming Growth Factor beta; Tumor Microenvironment
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251141
作者单位	Innate Lymphoid Cells and Cancer, Institute of Experimental Immunology, University of Zurich, Zurich, CH-8057, Switzerland; Tumor Immunology, Institute of Experimental Immunology, University of Zurich, Zurich, CH-8057, Switzerland; Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, CH-8057, Switzerland; Institute of Molecular Cancer Research, University of Zurich, Zurich, CH-8057, Switzerland
推荐引用方式 GB/T 7714	Ducimetière L.,Lucchiari G.,Litscher G.,et al. Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis[J],2021,118(27).
APA	Ducimetière L..,Lucchiari G..,Litscher G..,Nater M..,Heeb L..,...&Tugues S..(2021).Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis.Proceedings of the National Academy of Sciences of the United States of America,118(27).
MLA	Ducimetière L.,et al."Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis".Proceedings of the National Academy of Sciences of the United States of America 118.27(2021).