气候变化领域集成服务门户(CCPortal): Integration of signals from different cortical areas in higher order thalamic neurons

CCPortal

DOI	10.1073/pnas.2104137118
	Integration of signals from different cortical areas in higher order thalamic neurons
	Sampathkumar V.; Miller-Hansen A.; Murray Sherman S.; Kasthuri N.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:30
英文摘要	Higher order thalamic neurons receive driving inputs from cortical layer 5 and project back to the cortex, reflecting a transthalamic route for corticocortical communication. To determine whether or not individual neurons integrate signals from different cortical populations, we combined electron microscopy “connectomics” in mice with genetic labeling to disambiguate layer 5 synapses from somatosensory and motor cortices to the higher order thalamic posterior medial nucleus. A significant convergence of these inputs was found on 19 of 33 reconstructed thalamic cells, and as a population, the layer 5 synapses were larger and located more proximally on dendrites than were unlabeled synapses. Thus, many or most of these thalamic neurons do not simply relay afferent information but instead integrate signals as disparate in this case as those emanating from sensory and motor cortices. These findings add further depth and complexity to the role of the higher order thalamus in overall cortical functioning. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Connectomics; Corticothalamic; Electron microscopy; Sensorimotor
语种	英语
scopus关键词	animal experiment; article; connectome; dendrite; electron microscopy; male; mouse; nonhuman; sensorimotor cortex; synapse; thalamus; animal; brain cortex; cytology; gene expression regulation; genetics; metabolism; nerve cell; nerve cell network; nerve tract; pea; physiology; signal transduction; transgenic mouse; ascorbate peroxidase; plant protein; plasma retinol binding protein; Rbp4 protein, mouse; Animals; Ascorbate Peroxidases; Cerebral Cortex; Gene Expression Regulation; Male; Mice; Mice, Transgenic; Nerve Net; Neural Pathways; Neurons; Peas; Plant Proteins; Retinol-Binding Proteins, Plasma; Signal Transduction; Synapses; Thalamus
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251111
作者单位	Department of Neurobiology, University of Chicago, Chicago, IL 60637, United States; Biosciences Division, Argonne National Laboratory, Lemont, IL 60439, United States
推荐引用方式 GB/T 7714	Sampathkumar V.,Miller-Hansen A.,Murray Sherman S.,et al. Integration of signals from different cortical areas in higher order thalamic neurons[J],2021,118(30).
APA	Sampathkumar V.,Miller-Hansen A.,Murray Sherman S.,&Kasthuri N..(2021).Integration of signals from different cortical areas in higher order thalamic neurons.Proceedings of the National Academy of Sciences of the United States of America,118(30).
MLA	Sampathkumar V.,et al."Integration of signals from different cortical areas in higher order thalamic neurons".Proceedings of the National Academy of Sciences of the United States of America 118.30(2021).