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DOI10.1073/pnas.2102718118
EZH2 inhibits NK cell–mediated antitumor immunity by suppressing CXCL10 expression in an HDAC10-dependent manner
Bugide S.; Gupta R.; Green M.R.; Wajapeyee N.
发表日期2021
ISSN0027-8424
卷号118期号:30
英文摘要Enhancer of zeste homolog 2 (EZH2) is a histone H3 lysine 27 methyltransferase that has been shown to function as an oncogene in some cancers. Previous reports have largely focused on the ability of EZH2 to regulate cell-intrinsic tumor regulatory pathways as its mechanism-of-oncogenic action. However, the role that EZH2-mediated immune suppression plays in its oncogenic activity is not fully known. In particular, the role of natural killer (NK) cells in EZH2-driven tumor growth remains incompletely understood. Here, we demonstrate that genetic or pharmacological inhibition of EZH2 induces reexpression of the chemokine CXCL10 in hepatic tumor cells. We find that histone deacetylase 10 (HDAC10) is necessary for EZH2 recruitment to the CXCL10 promoter, leading to CXCL10 transcriptional repression. Critically, CXCL10 is necessary and sufficient for stimulating NK cell migration, and EZH2’s ability to inhibit NK cell migration via CXCL10 suppression is conserved in other EZH2-dependent cancers. NK cell depletion in an immunocompetent syngeneic mouse model of hepatic tumorigenesis reverses the tumor inhibitory effects of an EZH2 inhibitor (GSK343), and inhibitor-mediated reexpression of CXCL10 is required for its tumor suppressive effects in the same mouse model. Collectively, these results reveal a decisive role for NK cells and CXCL10 in mediating the oncogenic function of EZH2. © 2021 National Academy of Sciences. All rights reserved.
英文关键词CXCL10; EZH2; HDAC10; Hepatocellular carcinoma; NK cells
语种英语
scopus关键词benzopyran derivative; chemokine; CXCL10 protein, human; decitabine; dipyrone; EED226; enzyme inhibitor; EZH2 protein, human; gamma interferon inducible protein 10; GSK-2816126; GSK343; HDAC10 protein, human; histone deacetylase; indazole derivative; indole derivative; phenol derivative; sulfone; theasinensin A; transcription factor EZH2; triazole derivative; animal; C57BL mouse; cell motion; drug effect; experimental neoplasm; gene expression regulation; genetics; human; immunology; liver cell carcinoma; liver tumor; male; metabolism; mouse; natural killer cell; tumor cell line; Animals; Benzopyrans; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Chemokine CXCL10; Chemokines; Decitabine; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Histone Deacetylases; Humans; Indazoles; Indoles; Killer Cells, Natural; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Phenols; Pyridones; Sulfones; Triazoles
来源期刊Proceedings of the National Academy of Sciences of the United States of America
文献类型期刊论文
条目标识符http://gcip.llas.ac.cn/handle/2XKMVOVA/251105
作者单位Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35233, United States; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, United States
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Bugide S.,Gupta R.,Green M.R.,等. EZH2 inhibits NK cell–mediated antitumor immunity by suppressing CXCL10 expression in an HDAC10-dependent manner[J],2021,118(30).
APA Bugide S.,Gupta R.,Green M.R.,&Wajapeyee N..(2021).EZH2 inhibits NK cell–mediated antitumor immunity by suppressing CXCL10 expression in an HDAC10-dependent manner.Proceedings of the National Academy of Sciences of the United States of America,118(30).
MLA Bugide S.,et al."EZH2 inhibits NK cell–mediated antitumor immunity by suppressing CXCL10 expression in an HDAC10-dependent manner".Proceedings of the National Academy of Sciences of the United States of America 118.30(2021).
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