气候变化领域集成服务门户(CCPortal): Astrocyte-derived neurons provide excitatory input to the adult striatal circuitry

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DOI	10.1073/pnas.2104119118
	Astrocyte-derived neurons provide excitatory input to the adult striatal circuitry
	Dorst M.C.; Díaz-Moreno M.; Dias D.O.; Guimarães E.L.; Holl D.; Kalkitsas J.; Silberberg G.; Göritz C.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:33
英文摘要	Astrocytes have emerged as a potential source for new neurons in the adult mammalian brain. In mice, adult striatal neurogenesis can be stimulated by local damage, which recruits striatal astrocytes into a neurogenic program by suppression of active Notch signaling (J. P. Magnusson et al., Science 346, 237-241 [2014]). Here, we induced adult striatal neurogenesis in the intact mouse brain by the inhibition of Notch signaling in astrocytes. We show that most striatal astrocyte-derived neurons are confined to the anterior medial striatum, do not express established striatal neuronal markers, and exhibit dendritic spines, which are atypical for striatal interneurons. In contrast to striatal neurons generated during development, which are GABAergic or cholinergic, most adult astrocyte-derived striatal neurons possess distinct electrophysiological properties, constituting the only glutamatergic striatal population. Astrocyte-derived neurons integrate into the adult striatal microcircuitry, both receiving and providing synaptic input. The glutamatergic nature of these neurons has the potential to provide excitatory input to the striatal circuitry and may represent an efficient strategy to compensate for reduced neuronal activity caused by aging or lesion-induced neuronal loss. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Astrocyte-derived neurogenesis; Glutamatergic; Neurons; Striatum
语种	英语
scopus关键词	adult; aging; animal cell; animal experiment; article; astrocyte; controlled study; corpus striatum; dendritic spine; interneuron; male; mouse; nervous system development; nonhuman; Notch signaling; synapse; animal; astrocyte; cell differentiation; drug effect; electrophysiology; enzymology; gene expression regulation; genetic recombination; genetics; metabolism; nerve cell; physiology; transgenic mouse; 4 aminobutyric acid receptor; 5-ethynyl-2'-deoxyuridine; connexin 30; deoxyuridine; Gjb6 protein, mouse; glutamic acid; neuronal nitric oxide synthase; photoprotein; tamoxifen; Animals; Astrocytes; Cell Differentiation; Connexin 30; Deoxyuridine; Electrophysiological Phenomena; GABAergic Neurons; Gene Expression Regulation; Glutamic Acid; Interneurons; Luminescent Proteins; Mice; Mice, Transgenic; Neurons; Nitric Oxide Synthase Type I; Recombination, Genetic; Tamoxifen
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251072
作者单位	Department of Neuroscience, Karolinska Institutet, Stockholm, SE-171 77, Sweden; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, SE-171 77, Sweden; Ming Wai Lau Centre for Reparative Medicine, Stockholm Node, Karolinska Institutet, Stockholm, SE-17177, Sweden
推荐引用方式 GB/T 7714	Dorst M.C.,Díaz-Moreno M.,Dias D.O.,et al. Astrocyte-derived neurons provide excitatory input to the adult striatal circuitry[J],2021,118(33).
APA	Dorst M.C..,Díaz-Moreno M..,Dias D.O..,Guimarães E.L..,Holl D..,...&Göritz C..(2021).Astrocyte-derived neurons provide excitatory input to the adult striatal circuitry.Proceedings of the National Academy of Sciences of the United States of America,118(33).
MLA	Dorst M.C.,et al."Astrocyte-derived neurons provide excitatory input to the adult striatal circuitry".Proceedings of the National Academy of Sciences of the United States of America 118.33(2021).