气候变化领域集成服务门户(CCPortal): Natural variation identifies SNI1, the SMC5/6 component, as a modifier of meiotic crossover in Arabidopsis

CCPortal

DOI	10.1073/pnas.2021970118
	Natural variation identifies SNI1, the SMC5/6 component, as a modifier of meiotic crossover in Arabidopsis
	Zhu L.; Fernández-Jiménez N.; Szymanska-Lejman M.; Pelé A.; Underwood C.J.; Serra H.; Lambing C.; Dluzewska J.; Bieluszewski T.; Pradillo M.; Henderson I.R.; Ziolkowski P.A.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:33
英文摘要	The frequency and distribution of meiotic crossovers are tightly controlled; however, variation in this process can be observed both within and between species. Using crosses of two natural Arabidopsis thaliana accessions, Col and Ler, we mapped a crossover modifier locus to semidominant polymorphisms in SUPPRESSOR OF NPR1-1 INDUCIBLE 1 (SNI1), which encodes a component of the SMC5/6 complex. The sni1 mutant exhibits a modified pattern of recombination across the genome with crossovers elevated in chromosome distal regions but reduced in pericentromeres. Mutations in SNI1 result in reduced crossover interference and can partially restore the fertility of a Class I crossover pathway mutant, which suggests that the protein affects noninterfering crossover repair. Therefore, we tested genetic interactions between SNI1 and both RECQ4 and FANCM DNA helicases, which showed that additional Class II crossovers observed in the sni1 mutant are FANCM independent. Furthermore, genetic analysis of other SMC5/6 mutants confirms the observations of crossover redistribution made for SNI1. The study reveals the importance of the SMC5/6 complex in ensuring the proper progress of meiotic recombination in plants. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Arabidopsis; Crossover; Meiosis; SMC5/6; SNI1
语种	英语
scopus关键词	DNA helicase; Arabidopsis protein; DNA helicase; FANCM protein, Arabidopsis; nuclear protein; RecQ4A protein, Arabidopsis; SNI1 protein, Arabidopsis; Arabidopsis thaliana; Article; controlled study; DNA polymorphism; gene identification; gene interaction; gene locus; gene mutation; genetic analysis; genetic variation; meiotic recombination; nonhuman; plant gene; signal transduction; SNI1 gene; Arabidopsis; crossing over; gene expression regulation; genetics; meiosis; metabolism; physiology; protein domain; Arabidopsis; Arabidopsis Proteins; Crossing Over, Genetic; DNA Helicases; Gene Expression Regulation, Plant; Genetic Variation; Meiosis; Nuclear Proteins; Protein Domains
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/251069
作者单位	Laboratory of Genome Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Poznan, 61-614, Poland; Departamento de Genética, Fisiología y Microbiología, Facultad de Ciencias Biológicas, Universidad Complutense de Madrid, Madrid, 28040, Spain; Department of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, United Kingdom; Department of Chromosome Biology, Max Planck Institute for Plant Breeding Research, Cologne, 50829, Germany; Genetics, Diversity and Ecophysiology of Cereals, Université Clermont Auvergne, Clermont-Ferrand, 63000, France
推荐引用方式 GB/T 7714	Zhu L.,Fernández-Jiménez N.,Szymanska-Lejman M.,et al. Natural variation identifies SNI1, the SMC5/6 component, as a modifier of meiotic crossover in Arabidopsis[J],2021,118(33).
APA	Zhu L..,Fernández-Jiménez N..,Szymanska-Lejman M..,Pelé A..,Underwood C.J..,...&Ziolkowski P.A..(2021).Natural variation identifies SNI1, the SMC5/6 component, as a modifier of meiotic crossover in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America,118(33).
MLA	Zhu L.,et al."Natural variation identifies SNI1, the SMC5/6 component, as a modifier of meiotic crossover in Arabidopsis".Proceedings of the National Academy of Sciences of the United States of America 118.33(2021).