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DOI	10.1073/pnas.2109381118
	Epoxidation of juvenile hormone was a key innovation improving insect reproductive fitness
	Nouzova M.; Edwards M.J.; Michalkova V.; Ramirez C.E.; Ruiz M.; Areiza M.; DeGennaro M.; Fernandez-Lima F.; Feyereisen R.; Jindra M.; Noriega F.G.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:45
英文摘要	Methyl farnesoate (MF) plays hormonal regulatory roles in crustaceans. An epoxidated form of MF, known as juvenile hormone (JH), controls metamorphosis and stimulates reproduction in insects. To address the evolutionary significance of MF epoxidation, we generated mosquitoes completely lacking either of the two enzymes that catalyze the last steps of MF/JH biosynthesis and epoxidation, respectively: The JH acid methyltransferase (JHAMT) and the P450 epoxidase CYP15 (EPOX). jhamt2/2 larvae lacking both MF and JH died at the onset of metamorphosis. Strikingly, epox2/2 mutants, which synthesized MF but no JH, completed the entire life cycle. While epox2/2 adults were fertile, the reproductive performance of both sexes was dramatically reduced. Our results suggest that although MF can substitute for the absence of JH in mosquitoes, it is with a significant fitness cost. We propose that MF can fulfill most roles of JH, but its epoxidation to JH was a key innovation providing insects with a reproductive advantage. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Aedes aegypti; Corpora allata; Methyl farnesoate; Reproduction; uvenile hormone
语种	英语
scopus关键词	cytochrome P450; juvenile hormone; sesquiterpenoid; juvenile hormone; methyl farnesoate; sesquiterpene; unsaturated fatty acid; adult; Aedes aegypti; animal experiment; animal tissue; Article; biosynthesis; controlled study; down regulation; embryo; enzyme mechanism; epox gene; epoxidation; female; gene; gene expression regulation; jhamt gene; larval stage; male; mating success; metamorphosis; nonhuman; null allele; phenotype; reproductive fitness; signal transduction; Aedes; animal; biosynthesis; enzymology; genetics; metabolism; molecular evolution; reproduction; sexual behavior; Aedes; Animals; Evolution, Molecular; Fatty Acids, Unsaturated; Female; Genetic Fitness; Juvenile Hormones; Male; Metamorphosis, Biological; Reproduction; Sesquiterpenes; Sexual Behavior, Animal
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/250995
作者单位	Department of Biological Sciences, Biomolecular Science Institute, Florida International University, Miami, FL 33199, United States; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, 37005, Czech Republic; Department of Biology, Muhlenberg College, Allentown, PA 18104, United States; Institute of Zoology, Slovak Academy of Sciences, Bratislava, 84506, Slovakia; Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, United States; Department of Plants and Crops, Faculty of Bioscience Engineering, Ghent University, Ghent, B-9000, Belgium; Department of Plant and Environmental Sciences, University of Copenhagen, Copenhagen, DK-1871, Denmark; Institute of Entomology, Biology Centre, Czech Academy of Sciences Ceske, Budejovice, 37005, Czech Republic
推荐引用方式 GB/T 7714	Nouzova M.,Edwards M.J.,Michalkova V.,et al. Epoxidation of juvenile hormone was a key innovation improving insect reproductive fitness[J],2021,118(45).
APA	Nouzova M..,Edwards M.J..,Michalkova V..,Ramirez C.E..,Ruiz M..,...&Noriega F.G..(2021).Epoxidation of juvenile hormone was a key innovation improving insect reproductive fitness.Proceedings of the National Academy of Sciences of the United States of America,118(45).
MLA	Nouzova M.,et al."Epoxidation of juvenile hormone was a key innovation improving insect reproductive fitness".Proceedings of the National Academy of Sciences of the United States of America 118.45(2021).