气候变化领域集成服务门户(CCPortal): Trading bits in the readout from a genetic network

CCPortal

DOI	10.1073/pnas.2109011118
	Trading bits in the readout from a genetic network
	Bauer M.; Petkova M.D.; Gregor T.; Wieschaus E.F.; Bialek W.
发表日期	2021
ISSN	1091-6490
卷号	118 期号:46
英文摘要	In the regulation of gene expression, information of relevance to the organism is represented by the concentrations of transcription factor molecules. To extract this information the cell must effectively "measure" these concentrations, but there are physical limits to the precision of these measurements. We use the gap gene network in the early fly embryo as an example of the tradeoff between the precision of concentration measurements and the transmission of relevant information. For thresholded measurements we find that lower thresholds are more important, and fine tuning is not required for near-optimal information transmission. We then consider general sensors, constrained only by a limit on their information capacity, and find that thresholded sensors can approach true information theoretic optima. The information theoretic approach allows us to identify the optimal sensor for the entire gap gene network and to argue that the physical limitations of sensing necessitate the observed multiplicity of enhancer elements, with sensitivities to combinations rather than single transcription factors.
英文关键词	development; gene regulation; information bottleneck; sensing
语种	英语
scopus关键词	transcription factor; animal; biological model; Diptera; gene expression regulation; gene regulatory network; genetics; Animals; Diptera; Gene Expression Regulation; Gene Regulatory Networks; Models, Biological; Transcription Factors
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/250984
作者单位	Joseph Henry Laboratories of Physics, Princeton University, Princeton, NJ 08544; mb67@princeton.edu wbialek@princeton.edu; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, United States; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, United States; Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, United States; Program in Biophysics, Harvard University, Cambridge, MA 02138; Joseph Henry Laboratories of Physics, Princeton University, Princeton, NJ 08544, United States; Department of Developmental and Stem Cell Biology, Institut Pasteur, Paris, 75015, France; Initiative for the Theoretical Sciences, Graduate Center, City University of New York, NY, NY 10016
推荐引用方式 GB/T 7714	Bauer M.,Petkova M.D.,Gregor T.,et al. Trading bits in the readout from a genetic network[J],2021,118(46).
APA	Bauer M.,Petkova M.D.,Gregor T.,Wieschaus E.F.,&Bialek W..(2021).Trading bits in the readout from a genetic network.Proceedings of the National Academy of Sciences of the United States of America,118(46).
MLA	Bauer M.,et al."Trading bits in the readout from a genetic network".Proceedings of the National Academy of Sciences of the United States of America 118.46(2021).