气候变化领域集成服务门户(CCPortal): The crucial role of genome-wide genetic variation in conservation

CCPortal

DOI	10.1073/pnas.2104642118
	The crucial role of genome-wide genetic variation in conservation
	Kardos M.; Armstrong E.E.; Fitzpatrick S.W.; Hauser S.; Hedrick P.W.; Miller J.M.; Tallmon D.A.; Chris Funk W.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:48
英文摘要	The unprecedented rate of extinction calls for efficient use of genetics to help conserve biodiversity. Several recent genomic and simulation-based studies have argued that the field of conservation biology has placed too much focus on conserving genome-wide genetic variation, and that the field should instead focus on managing the subset of functional genetic variation that is thought to affect fitness. Here, we critically evaluate the feasibility and likely benefits of this approach in conservation. We find that population genetics theory and empirical results show that conserving genome-wide genetic variation is generally the best approach to prevent inbreeding depression and loss of adaptive potential from driving populations toward extinction. Focusing conservation efforts on presumably functional genetic variation will only be feasible occasionally, often misleading, and counterproductive when prioritized over genome-wide genetic variation. Given the increasing rate of habitat loss and other environmental changes, failure to recognize the detrimental effects of lost genome-wide genetic variation on long-term population viability will only worsen the biodiversity crisis. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Extinction; Genomics; Population dynamics
语种	英语
scopus关键词	article; biodiversity; environmental change; feasibility study; genetic variation; genomics; habitat; inbreeding depression; population dynamics; population genetics; theoretical study; animal; ecosystem; environmental protection; genetic variation; genetics; genome; genomics; inbreeding; metagenomics; population dynamics; procedures; reproductive fitness; Animals; Biodiversity; Conservation of Natural Resources; Ecosystem; Genetic Fitness; Genetic Variation; Genetics; Genetics, Population; Genome; Genomics; Inbreeding; Metagenomics; Population Dynamics
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/250965
作者单位	Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Seattle, WA 98112, United States; Department of Biology, Stanford University, Stanford, CA 94305, United States; W.K. Kellogg Biological Station, Michigan State University, Hickory Corners, MI 49060, United States; Department of Integrative Biology, Michigan State University, East Lansing, MI 48824, United States; Ecology, Evolution, and Behavior Program, Michigan State University, East Lansing, MI 48824, United States; Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, United States; School of Life Sciences, Arizona State University, Tempe, AZ 85287, United States; San Diego Zoo Wildlife Alliance, Escondido, CA 92027, United States; Polar Bears International, Bozeman, MT 59772, United States; Department of Biological Sciences, MacEwan University, Edmonton, AB T5J 4S2, Canada; Biology and Marine Biology Program, University of Alaska South...
推荐引用方式 GB/T 7714	Kardos M.,Armstrong E.E.,Fitzpatrick S.W.,et al. The crucial role of genome-wide genetic variation in conservation[J],2021,118(48).
APA	Kardos M..,Armstrong E.E..,Fitzpatrick S.W..,Hauser S..,Hedrick P.W..,...&Chris Funk W..(2021).The crucial role of genome-wide genetic variation in conservation.Proceedings of the National Academy of Sciences of the United States of America,118(48).
MLA	Kardos M.,et al."The crucial role of genome-wide genetic variation in conservation".Proceedings of the National Academy of Sciences of the United States of America 118.48(2021).