气候变化领域集成服务门户(CCPortal): Local acetate inhibits brown adipose tissue function

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DOI	10.1073/pnas.2116125118
	Local acetate inhibits brown adipose tissue function
	Sun W.; Dong H.; Wolfrum C.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:49
英文摘要	Brown adipose tissue has been extensively studied in the last decade for its potential to counteract the obesity pandemic. However, the paracrine regulation within brown tissue is largely unknown. Here, we show that local acetate directly inhibits brown fat thermogenesis, without changing acetate levels in the circulation. We demonstrate that modulating acetate within brown tissue at physiological levels blunts its function and systemically decreases energy expenditure. Using a series of transcriptomic analyses, we identified genes related to the tricarboxylic acid cycle and brown adipocyte formation, which are down-regulated upon local acetate administration. Overall, these findings demonstrate that local acetate inhibits brown fat function. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Acetate; Brown adipose tissue; Obesity; RNA-seq
语种	英语
scopus关键词	acetic acid; beta 3 adrenergic receptor; sodium chloride; uncoupling protein 1; acetic acid; transcriptome; adult; animal tissue; Article; brown adipocyte; brown adipose tissue; citric acid cycle; controlled study; down regulation; energy expenditure; hierarchical clustering; histology; immunohistology; interscapular brown adipose tissue; male; mouse; nonhuman; obesity; principal component analysis; protein expression; RNA sequencing; thermogenesis; transcriptomics; animal; brown adipose tissue; C57BL mouse; drug effect; eating; energy metabolism; gene expression; gene expression profiling; gene expression regulation; genetics; lipid diet; metabolism; physiology; procedures; white adipose tissue; Acetates; Adipocytes, Brown; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Citric Acid Cycle; Diet, High-Fat; Eating; Energy Metabolism; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Obesity; Thermogenesis; Transcriptome
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/250954
作者单位	Institute of Food, Nutrition, and Health, Eidgenossiche € Technische Hochschule Zurich, Zurich, CH 8603, Switzerland
推荐引用方式 GB/T 7714	Sun W.,Dong H.,Wolfrum C.. Local acetate inhibits brown adipose tissue function[J],2021,118(49).
APA	Sun W.,Dong H.,&Wolfrum C..(2021).Local acetate inhibits brown adipose tissue function.Proceedings of the National Academy of Sciences of the United States of America,118(49).
MLA	Sun W.,et al."Local acetate inhibits brown adipose tissue function".Proceedings of the National Academy of Sciences of the United States of America 118.49(2021).