气候变化领域集成服务门户(CCPortal): hox gene expression predicts tetrapod-like axial regionalization in the skate, Leucoraja erinacea

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DOI	10.1073/pnas.2114563118
	hox gene expression predicts tetrapod-like axial regionalization in the skate, Leucoraja erinacea
	Criswell K.E.; Roberts L.E.; Koo E.T.; Head J.J.; Andrew Gillis J.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:51
英文摘要	The axial skeleton of tetrapods is organized into distinct anteroposterior regions of the vertebral column (cervical, trunk, sacral, and caudal), and transitions between these regions are determined by colinear anterior expression boundaries of Hox5/6, -9, -10, and -11 paralogy group genes within embryonic paraxial mesoderm. Fishes, conversely, exhibit little in the way of discrete axial regionalization, and this has led to scenarios of an origin of Hox-mediated axial skeletal complexity with the evolutionary transition to land in tetrapods. Here, combining geometric morphometric analysis of vertebral column morphology with cell lineage tracing of hox gene expression boundaries in developing embryos, we recover evidence of at least five distinct regions in the vertebral skeleton of a cartilaginous fish, the little skate (Leucoraja erinacea). We find that skate embryos exhibit tetrapod-like anteroposterior nesting of hox gene expression in their paraxial mesoderm, and we show that anterior expression boundaries of hox5/6, hox9, hox10, and hox11 paralogy group genes predict regional transitions in the differentiated skate axial skeleton. Our findings suggest that hox-based axial skeletal regionalization did not originate with tetrapods but rather has a much deeper evolutionary history than was previously appreciated. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Chondrichthyan; Hox genes; Regionalization; Vertebral column
语种	英语
scopus关键词	article; cell lineage; controlled study; embryo; Hox gene; Leucoraja erinacea; mesoderm; nesting; nonhuman; paralogy; protein expression; regionalization; skeleton; spine; tetrapod; animal; body patterning; embryology; evolution; gene expression regulation; genetics; growth, development and aging; homeobox; metabolism; physiology; spine; homeodomain protein; Animals; Biological Evolution; Body Patterning; Gene Expression Regulation, Developmental; Genes, Homeobox; Homeodomain Proteins; Skates, Fish; Spine
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/250922
作者单位	Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, United Kingdom; University Museum of Zoology, University of Cambridge, Cambridge, CB2 3EJ, United Kingdom; Marine Biological Laboratory, Woods HoleMA 02543, United States
推荐引用方式 GB/T 7714	Criswell K.E.,Roberts L.E.,Koo E.T.,et al. hox gene expression predicts tetrapod-like axial regionalization in the skate, Leucoraja erinacea[J],2021,118(51).
APA	Criswell K.E.,Roberts L.E.,Koo E.T.,Head J.J.,&Andrew Gillis J..(2021).hox gene expression predicts tetrapod-like axial regionalization in the skate, Leucoraja erinacea.Proceedings of the National Academy of Sciences of the United States of America,118(51).
MLA	Criswell K.E.,et al."hox gene expression predicts tetrapod-like axial regionalization in the skate, Leucoraja erinacea".Proceedings of the National Academy of Sciences of the United States of America 118.51(2021).