气候变化领域集成服务门户(CCPortal): Selection on adaptive and maladaptive gene expression plasticity during thermal adaptation to urban heat islands

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DOI	10.1038/s41467-021-26334-4
	Selection on adaptive and maladaptive gene expression plasticity during thermal adaptation to urban heat islands
	Campbell-Staton S.C.; Velotta J.P.; Winchell K.M.
发表日期	2021
ISSN	2041-1723
卷号	12 期号:1
英文摘要	Phenotypic plasticity enables a single genotype to produce multiple phenotypes in response to environmental variation. Plasticity may play a critical role in the colonization of novel environments, but its role in adaptive evolution is controversial. Here we suggest that rapid parallel regulatory adaptation of Anolis lizards to urban heat islands is due primarily to selection for reduced and/or reversed heat-induced plasticity that is maladaptive in urban thermal conditions. We identify evidence for polygenic selection across genes of the skeletal muscle transcriptome associated with heat tolerance. Forest lizards raised in common garden conditions exhibit heat-induced changes in expression of these genes that largely correlate with decreased heat tolerance, consistent with maladaptive regulatory response to high-temperature environments. In contrast, urban lizards display reduced gene expression plasticity after heat challenge in common garden and a significant increase in gene expression change that is congruent with greater heat tolerance, a putatively adaptive state in warmer urban environments. Genes displaying maladaptive heat-induced plasticity repeatedly show greater genetic divergence between urban and forest habitats than those displaying adaptive plasticity. These results highlight the role of selection against maladaptive regulatory plasticity during rapid adaptive modification of complex systems in the wild. © 2021, The Author(s).
语种	英语
scopus关键词	transcriptome; transcriptome; adaptation; colonization; gene expression; genotype; heat island; adult; Anolis; Article; controlled study; female; forest; functional enrichment analysis; gene expression; gene linkage disequilibrium; genetic variability; habitat; heat; heat tolerance; high temperature; island (geological); male; natural selection; nonhuman; phenotype; phenotypic plasticity; single nucleotide polymorphism; skeletal muscle; temperature acclimatization; urban area; adaptation; animal; city; gene regulatory network; genetic selection; genetic variation; genetics; lizard; metabolism; molecular evolution; physiology; Puerto Rico; Anolis; Squamata; Adaptation, Physiological; Animals; Cities; Evolution, Molecular; Forests; Gene Regulatory Networks; Genetic Variation; Hot Temperature; Lizards; Muscle, Skeletal; Puerto Rico; Selection, Genetic; Thermotolerance; Transcriptome
来源期刊	Nature Communications
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/250590
作者单位	Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08540, United States; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA 90095, United States; Institute for Society and Genetics, University of California, Los Angeles, CA 90095, United States; Department of Biological Sciences, University of Denver, Denver, CO 80208, United States; Biology Department, Washington University, St. Louis, MO, United States
推荐引用方式 GB/T 7714	Campbell-Staton S.C.,Velotta J.P.,Winchell K.M.. Selection on adaptive and maladaptive gene expression plasticity during thermal adaptation to urban heat islands[J],2021,12(1).
APA	Campbell-Staton S.C.,Velotta J.P.,&Winchell K.M..(2021).Selection on adaptive and maladaptive gene expression plasticity during thermal adaptation to urban heat islands.Nature Communications,12(1).
MLA	Campbell-Staton S.C.,et al."Selection on adaptive and maladaptive gene expression plasticity during thermal adaptation to urban heat islands".Nature Communications 12.1(2021).