气候变化领域集成服务门户(CCPortal): Asthma mortality is triggered by short-term exposures to ambient air pollutants: Evidence from a Chinese urban population

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DOI	10.1016/j.atmosenv.2020.117271
	Asthma mortality is triggered by short-term exposures to ambient air pollutants: Evidence from a Chinese urban population
	Zhang Y.; Xiang Q.; Yu C.; Yang Z.
发表日期	2020
ISSN	1352-2310
卷号	223
英文摘要	Background: Short-term exposure to ambient air pollution (AAP) has been widely linked to asthma morbidity such as outpatient and emergency visits and hospitalization. Up to date, however, the acute effects of AAP exposure on asthma mortality remained largely unknown possibly due to the rare occurrence of asthma deaths. Objectives: This study aimed to investigate whether the death risks from asthma are triggered by short-term AAP exposures in a Chinese urban population who suffered poor air quality. Methods: 1385 asthma death cases were identified from the total 61.3 thousand death records in two urban districts in Wuhan, central China, 2003–2013. We performed a time-stratified case-crossover design and conditional logistic regression models were applied to assess short-term associations of air pollutants (particulate matter with aerodynamic diameter ≤10 μm [PM10], sulfur dioxide [SO2], and nitrogen dioxide [NO2]) along different exposure days with asthma mortality. Results: A total of 1385 case days and 4668 control days were investigated during the study period. Daily mean concentrations of PM10, SO2, and NO2 were 116.6 μg/m3, 53.4 μg/m3, and 60.7 μg/m3, respectively. A 10 μg/m3 rise in exposure to SO2 and NO2 at 2 days prior to death (lag 2 days), was associated with increased asthma death risks of 2.9% (odds ratio [OR] = 1.029, 95% confidence interval [CI]: 1.006, 1.053) and 4.3% (OR = 1.043, 95% CI: 1.012, 1.076), respectively. No evident PM10-asthma associations were identified in all subpopulations except for those aged 85+ years (OR = 1.022, 95% CI: 1.001 to 1.044). In our stratified analyses, significant effects of SO2 and NO2 were only observed in female, the older elderly, 7+ years-educated and unmarried persons, as well as those died outside the hospital and in cold season. We observed some evidence for effect modification by age, with p-values of 0.032 for PM10 and 0.051 for SO2, suggesting higher vulnerability to air pollution among the older asthma cases. Conclusions: This study provided suggestive evidence for the short-term association between air pollution exposure and asthma death in highly polluted urban areas. Several days’ high-level exposures to air pollutants, particularly SO2 and NO2, may elevate risks of asthma death. Our findings highlighted the potential health benefits from intervention and preventive actions targeted to reducing AAP exposure among asthma patients. © 2020 Elsevier Ltd
关键词	Air pollution Asthma mortality Case-crossover study China Short-term effects
语种	英语
scopus关键词	Air pollution; Air quality; Hospitals; Logistic regression; Nitrogen oxides; Patient treatment; Sulfur dioxide; Aerodynamic diameters; Air pollution exposures; Asthma mortality; Case crossovers; Case-crossover designs; China; Conditional logistic regressions; Short-term effects; Diseases; nitrogen dioxide; sulfur dioxide; ambient air; asthma; atmospheric pollution; confidence interval; mortality; pollution exposure; urban population; vulnerability; adolescent; adult; aged; air pollution; air quality; ambient air; Article; asthma; child; Chinese; cold; controlled study; educational status; environmental exposure; female; human; major clinical study; male; middle aged; mortality; mortality risk; particulate matter; priority journal; school child; season; urban population; very elderly; young adult; China; Hubei; Wuhan
来源期刊	ATMOSPHERIC ENVIRONMENT
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/249355
作者单位	Department of Epidemiology and Health Statistics, School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan, 430065, China; Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan, 430065, China; Hubei Provincial Center for Disease Control and Prevention, Wuhan, 430079, China; Department of Preventive Medicine, School of Health Sciences, Wuhan University, Wuhan, 430071, China; Donlinks School of Economics and Management, University of Science and Technology Beijing, Beijing, 100083, China
推荐引用方式 GB/T 7714	Zhang Y.,Xiang Q.,Yu C.,et al. Asthma mortality is triggered by short-term exposures to ambient air pollutants: Evidence from a Chinese urban population[J],2020,223.
APA	Zhang Y.,Xiang Q.,Yu C.,&Yang Z..(2020).Asthma mortality is triggered by short-term exposures to ambient air pollutants: Evidence from a Chinese urban population.ATMOSPHERIC ENVIRONMENT,223.
MLA	Zhang Y.,et al."Asthma mortality is triggered by short-term exposures to ambient air pollutants: Evidence from a Chinese urban population".ATMOSPHERIC ENVIRONMENT 223(2020).